LKT Product ID Name Unit Size Retail Price Short Description Chemical Name Synonym CAS Number Purity Specification Formula Weight Formula SMILES Stability Ship Temp Storage Temp Optical Rotation Solubility References Chemical Hazard Code UN Number S8044 R,S-Sulforaphane 100 mg 367.5 Synthetic ITC. 1-Isothiocyanato-4-(methylsulfinyl)-butane D,L-Sulforaphane 4478-93-7 ≥98% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S Stable for 2 years at -20°C. Avoid prolonged contact with moisture and freeze thaw cycles. Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Lee JH, Jeong JK, Park SY. Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway. Neuroscience. 2014 Oct 10;278:31-9. PMID: 25130556. Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Nallasamy P, Si H, Babu PV, et al. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem. 2014 Aug;25(8):824-33. PMID: 24880493. Pinz S, Unser S, Rascle A. The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One. 2014 Jun 9;9(6):e99391. PMID: 24910998. WuQ, Zong J, Gao L, et al. Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy. Herz. 2014 May;39(3):390-6. PMID: 23784363. Kleszczyński K, Ernst IM, Wagner AE, et al. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013 Dec;78:28-40. PMID: 24121007. Chuang WY, Kung PH, Kuo CY, et al. Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemost. 2013 Jun;109(6):1120-30. PMID: 23426129. Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep. 2013 Apr;29(4):1671-7. PMID: 23404329. Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862. Wu HZ, Fei HJ, Zhao YL, et al. Antibacterial mechanism of sulforaphane on Escherichia coli. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):386-90. PMID: 22812243. Do DP, Pai SB, Rizvi SA, et al. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010 Feb 15;386(1-2):114-21. PMID: 19922783. " Not dangerous goods. S8044 R,S-Sulforaphane 25 mg 123.9 Synthetic ITC. 1-Isothiocyanato-4-(methylsulfinyl)-butane D,L-Sulforaphane 4478-93-7 ≥98% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S Stable for 2 years at -20°C. Avoid prolonged contact with moisture and freeze thaw cycles. Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Lee JH, Jeong JK, Park SY. Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway. Neuroscience. 2014 Oct 10;278:31-9. PMID: 25130556. Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Nallasamy P, Si H, Babu PV, et al. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem. 2014 Aug;25(8):824-33. PMID: 24880493. Pinz S, Unser S, Rascle A. The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One. 2014 Jun 9;9(6):e99391. PMID: 24910998. Wu Q, Zong J, Gao L, et al. Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy. Herz. 2014 May;39(3):390-6. PMID: 23784363. Kleszczyński K, Ernst IM, Wagner AE, et al. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013 Dec;78:28-40. PMID: 24121007. Chuang WY, Kung PH, Kuo CY, et al. Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemost. 2013 Jun;109(6):1120-30. PMID: 23426129. Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep. 2013 Apr;29(4):1671-7. PMID: 23404329. Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862. Wu HZ, Fei HJ, Zhao YL, et al. Antibacterial mechanism of sulforaphane on Escherichia coli. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):386-90. PMID: 22812243. Do DP, Pai SB, Rizvi SA, et al. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010 Feb 15;386(1-2):114-21. PMID: 19922783. " Not dangerous goods. S8044 R,S-Sulforaphane 500 mg 1239 Synthetic ITC. 1-Isothiocyanato-4-(methylsulfinyl)-butane D,L-Sulforaphane 4478-93-7 ≥98% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S Stable for 2 years at -20°C. Avoid prolonged contact with moisture and freeze thaw cycles. Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Lee JH, Jeong JK, Park SY. Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway. Neuroscience. 2014 Oct 10;278:31-9. PMID: 25130556. Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Nallasamy P, Si H, Babu PV, et al. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem. 2014 Aug;25(8):824-33. PMID: 24880493. Pinz S, Unser S, Rascle A. The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One. 2014 Jun 9;9(6):e99391. PMID: 24910998. Wu Q, Zong J, Gao L, et al. Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy. Herz. 2014 May;39(3):390-6. PMID: 23784363. Kleszczyński K, Ernst IM, Wagner AE, et al. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013 Dec;78:28-40. PMID: 24121007. Chuang WY, Kung PH, Kuo CY, et al. Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemost. 2013 Jun;109(6):1120-30. PMID: 23426129. Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep. 2013 Apr;29(4):1671-7. PMID: 23404329. Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862. Wu HZ, Fei HJ, Zhao YL, et al. Antibacterial mechanism of sulforaphane on Escherichia coli. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):386-90. PMID: 22812243. Do DP, Pai SB, Rizvi SA, et al. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010 Feb 15;386(1-2):114-21. PMID: 19922783. " Not dangerous goods. S8044 R,S-Sulforaphane 50 mg 204.8 Synthetic ITC. 1-Isothiocyanato-4-(methylsulfinyl)-butane D,L-Sulforaphane 4478-93-7 ≥98% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S Stable for 2 years at -20°C. Avoid prolonged contact with moisture and freeze thaw cycles. Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Lee JH, Jeong JK, Park SY. Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway. Neuroscience. 2014 Oct 10;278:31-9. PMID: 25130556. Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Nallasamy P, Si H, Babu PV, et al. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem. 2014 Aug;25(8):824-33. PMID: 24880493. Pinz S, Unser S, Rascle A. The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One. 2014 Jun 9;9(6):e99391. PMID: 24910998. Wu Q, Zong J, Gao L, et al. Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy. Herz. 2014 May;39(3):390-6. PMID: 23784363. Kleszczyński K, Ernst IM, Wagner AE, et al. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013 Dec;78:28-40. PMID: 24121007. Chuang WY, Kung PH, Kuo CY, et al. Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemost. 2013 Jun;109(6):1120-30. PMID: 23426129. Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep. 2013 Apr;29(4):1671-7. PMID: 23404329. Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862. Wu HZ, Fei HJ, Zhao YL, et al. Antibacterial mechanism of sulforaphane on Escherichia coli. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):386-90. PMID: 22812243. Do DP, Pai SB, Rizvi SA, et al. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010 Feb 15;386(1-2):114-21. PMID: 19922783. " Not dangerous goods. S8046 R-Sulforaphane 10 mg 231 ITC found in cruciferous vegetables; AhR antagonist. 1-Isothiocyanato-4-(methylsulfinyl)-butane L-Sulforaphane 142825-10-3 ≥98% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862. Zanichelli F, Capasso S, Cipollaro M, et al. Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect. Age (Dordr). 2012 Apr;34(2):281-93. PMID: 21465338. Abdull Razis AF, Bagatta M, De Nicola GR, et al. Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Arch Toxicol. 2011 Aug;85(8):919-27. PMID: 21132492. Abdull Razis AF, Iori R, Ioannides C. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128(12):2775-82. PMID: 20726001. " Not dangerous goods. S8049 S-Sulforaphene 10 mg 257.3 ITC found in cruciferous vegetables. (-)4-Isothiocyanato-4R-(methylsulfinyl)-1-butene Raphanin; Sativin 592-95-0 ≥98% 175.27 C6H9NOS2 CS(=O)C=CCCN=C=S Ambient -20°C Soluble in water, methanol, DMSO, or chloroform. "Kim KH, Moon E, Kim SY, et al. 4-Methylthio-butanyl derivatives from the seeds of Raphanus sativus and their biological evaluation on anti-inflammatory and antitumor activities. J Ethnopharmacol. 2014;151(1):503-8. PMID: 24231071. Beevi SS, Mangamoori LN, Subathra M, et al. Hexane extract of Raphanus sativus L. roots inhibits cell proliferation and induces apoptosis in human cancer cells by modulating genes related to apoptotic pathway. Plant Foods Hum Nutr. 2010 Sep;65(3):200-9. PMID: 20652750. Brinker AM, Spencer GF. Herbicidal activity of sulforaphene from stock (Matthiola incana). J Chem Ecol. 1993 Oct;19(10):2279-84. PMID: 24248575. " Not dangerous goods. S8145 Sulindac 5 g 60.7 NSAID; COX-1/2 and PDE inhibitor. (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl) phenyl)methylene)-1H-indene-3-acetic acid Arthrocine; Sulindac sulfoxide; Clinoril; Clisundac; Reumofil 38194-50-2 ≥98% 356.42 C20H17FO3S CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O Ambient Ambient Soluble in DMSO (100 mM) or ethanol (25 mM). "Modi JP, Gharibani PM, Ma Z, et al. Protective mechanism of sulindac in an animal model of ischemic stroke. Brain Res. 2014 Aug 12;1576:91-9. PMID: 24968090. Li N, Xi Y, Tinsley HN, et al. Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling. Mol Cancer Ther. 2013 Sep;12(9):1848-59. PMID: 23804703. Li X, Gao L, Cui Q, et al. Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs. Oncogene. 2012 Nov 29;31(48):4979-86. PMID: 22286762. Scheper MA, Nikitakis NG, Chaisuparat R, et al. Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. PMID: 17401459. " Xn "UN number: 2811 Class: 6.1 Packing group: III Proper shipping name: Toxic solids, organic, n.o.s. (Sulindac) Marine pollutant: No Poison inhalation hazard: No" S8046 R-Sulforaphane 25 mg 451.5 ITC found in cruciferous vegetables; AhR antagonist. 1-Isothiocyanato-4-(methylsulfinyl)-butane L-Sulforaphane 142825-10-3 ≥98% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862. Zanichelli F, Capasso S, Cipollaro M, et al. Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect. Age (Dordr). 2012 Apr;34(2):281-93. PMID: 21465338. Abdull Razis AF, Bagatta M, De Nicola GR, et al. Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Arch Toxicol. 2011 Aug;85(8):919-27. PMID: 21132492. Abdull Razis AF, Iori R, Ioannides C. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128(12):2775-82. PMID: 20726001. " Not dangerous goods. S8146 Sulindac Sulfone 50 mg 123.8 NSAID; COX-1/2 and PDE inhibitor. 5-Fluoro-2-methy l-1-((4-(methylsulfonyl) phenyl)- methylene)-1H-indene-3-acetic acid 59864-04-9 ≥98% 372.41 C20H17FO4S CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O Ambient Ambient Soluble in DMSO or ethanol. "Modi JP, Gharibani PM, Ma Z, et al. Protective mechanism of sulindac in an animal model of ischemic stroke. Brain Res. 2014 Aug 12;1576:91-9. PMID: 24968090. Li N, Xi Y, Tinsley HN, et al. Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling. Mol Cancer Ther. 2013 Sep;12(9):1848-59. PMID: 23804703. Li X, Gao L, Cui Q, et al. Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs. Oncogene. 2012 Nov 29;31(48):4979-86. PMID: 22286762. Scheper MA, Nikitakis NG, Chaisuparat R, et al. Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. PMID: 17401459. " Not dangerous goods. S8146 Sulindac Sulfone 250 mg 356.7 NSAID; COX-1/2 and PDE inhibitor. 5-Fluoro-2-methy l-1-((4-(methylsulfonyl) phenyl)- methylene)-1H-indene-3-acetic acid 59864-04-9 ≥98% 372.41 C20H17FO4S CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O Ambient Ambient Soluble in DMSO or ethanol. "Modi JP, Gharibani PM, Ma Z, et al. Protective mechanism of sulindac in an animal model of ischemic stroke. Brain Res. 2014 Aug 12;1576:91-9. PMID: 24968090. Li N, Xi Y, Tinsley HN, et al. Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling. Mol Cancer Ther. 2013 Sep;12(9):1848-59. PMID: 23804703. Li X, Gao L, Cui Q, et al. Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs. Oncogene. 2012 Nov 29;31(48):4979-86. PMID: 22286762. Scheper MA, Nikitakis NG, Chaisuparat R, et al. Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. PMID: 17401459. " Not dangerous goods. T1849 Temozolomide 25 mg 81.6 Imidazotetrazine, DNA alkylator. 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5- tetrazine-8-carboxamide Methazolastone; Temodal; Temodar 85622-93-1 ≥98% 194.15 C6H6N6O2 CN1C(=O)N2C=NC(=C2N=N1)C(=O)N "Temozolomide was unstable at 37°C in human plasma with a degradation t1/2 of 15 min; however, it was stable at 4°C for at least 30 min. Temozolomide was stable in acidified human plasma (pH < 4) for at least 24 h at 25°C, and for at least 30 days at -20°C. Moreover, temozolomide was stable in acidified human plasma after being subjected to three freeze thaw cycles. J Pharm Biomed Anal. 2001 Jan;24(3):461-8" Ambient 4°C Soluble in DMSO to 39mg/mL, Water to 5 mg/mL, Ethanol <1mg/mL "Nagasawa DT, Chow F, Yew A, et al. Temozolomide and other potential agents for the treatment of glioblastoma multiforme. Neurosurg Clin N Am. 2012 Apr;23(2):307-22, ix. PMID: 22440874. Wesolowski JR, Rajdev P, Mukherji SK. Temozolomide (Temodar). AJNR Am J Neuroradiol. 2010 Sep;31(8):1383-4. PMID: 2053882. Friedman HS, Kerby T, Calvert H. Temozolomide and treatment of malignant glioma. Clin Cancer Res. 2000 Jul;6(7):2585-97. PMID: 10914698. Horing E, Harter PN, Seznec J, et al. The “go or grow” potential of gliomas is linked to the necropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress. Acta Neuropathol. 2012 Jul;124(1):83-97. PMID: 22249620. Momiyama M, Suetsugu A, Chishima T, et al. Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. Anticancer Res. 2013 Jan;33(1):103-106. PMID: 23267133. " Repr., Carc., Muta., Xn, Xi Not dangerous goods. T1849 Temozolomide 100 mg 224.3 Imidazotetrazine, DNA alkylator. 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5- tetrazine-8-carboxamide Methazolastone; Temodal; Temodar 85622-93-1 ≥98% 194.15 C6H6N6O2 CN1C(=O)N2C=NC(=C2N=N1)C(=O)N "Temozolomide was unstable at 37°C in human plasma with a degradation t1/2 of 15 min; however, it was stable at 4°C for at least 30 min. Temozolomide was stable in acidified human plasma (pH < 4) for at least 24 h at 25°C, and for at least 30 days at -20°C. Moreover, temozolomide was stable in acidified human plasma after being subjected to three freeze thaw cycles. J Pharm Biomed Anal. 2001 Jan;24(3):461-8" Ambient 4°C Soluble in DMSO to 39mg/mL, Water to 5 mg/mL, Ethanol <1mg/mL "Nagasawa DT, Chow F, Yew A, et al. Temozolomide and other potential agents for the treatment of glioblastoma multiforme. Neurosurg Clin N Am. 2012 Apr;23(2):307-22, ix. PMID: 22440874. Wesolowski JR, Rajdev P, Mukherji SK. Temozolomide (Temodar). AJNR Am J Neuroradiol. 2010 Sep;31(8):1383-4. PMID: 2053882. Friedman HS, Kerby T, Calvert H. Temozolomide and treatment of malignant glioma. Clin Cancer Res. 2000 Jul;6(7):2585-97. PMID: 10914698. Horing E, Harter PN, Seznec J, et al. The “go or grow” potential of gliomas is linked to the necropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress. Acta Neuropathol. 2012 Jul;124(1):83-97. PMID: 22249620. Momiyama M, Suetsugu A, Chishima T, et al. Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. Anticancer Res. 2013 Jan;33(1):103-106. PMID: 23267133. " Repr., Carc., Muta., Xn, Xi Not dangerous goods. S8169 Suramin Hexasodium 50 mg 97.2 RyR agonist, SIRT, telomerase, P2Y, GPCR inhibitor. 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino- (4-methyl-3,1-phenylene)-carbonylimino]]bis-1,3,5- naphthalenetrisulfonic acid hexasodium salt Suramin Sodium; Bayer 205; Antrypol; Germanin; Moranyl; Naganol; Naphuride 129-46-4 ≥98% 1429.19 C51H34N6O23S6Na6 CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] Hygroscopic. Ambient 4°C Soluble in water. Sparingly soluble in alcohol. Insoluble in benzene, ether or chloroform. "Wang Y, Qing J, Sun Y, et al. Suramin inhibits EV71 infection. Antiviral Res. 2014 Mar;103:1-6. PMID: 24374150. Marques AF, Esser D, Rosenthal PJ, et al. Falcipain-2 inhibition by suramin and suramin analogues. Bioorg Med Chem. 2013 Jul 1;21(13):3667-73. PMID: 23680445. Sakkiah S, Arooj M, Kumar MR, et al. Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations. PLoS One. 2013;8(1):e51429. PMID: 23382805. Erguven M, Akev N, Ozdemir A, et al. The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells. Med Sci Monit. 2008 Aug;14(8):BR165-73. PMID: 18667993. Abbracchio MP, Burnstock G, Boeynaems JM, et al. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 Sep;58(3):281-341. PMID: 16968944. Wolner I, Kassack MU, Ullmann H, et al. Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676. Br J Pharmacol. 2005 Oct;146(4):525-33. PMID: 16056233. Beindl W, Mitterauer T, Hohenegger M, et al. Inhibition of receptor/G protein coupling by suramin analogues. Mol Pharmacol. 1996 Aug;50(2):415-23. PMID: 8700151. " Not dangerous goods. S8169 Suramin Hexasodium 250 mg 396.2 RyR agonist, SIRT, telomerase, P2Y, GPCR inhibitor. 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino- (4-methyl-3,1-phenylene)-carbonylimino]]bis-1,3,5- naphthalenetrisulfonic acid hexasodium salt Suramin Sodium; Bayer 205; Antrypol; Germanin; Moranyl; Naganol; Naphuride 129-46-4 ≥98% 1429.19 C51H34N6O23S6Na6 CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] Hygroscopic. Ambient 4°C Soluble in water. Sparingly soluble in alcohol. Insoluble in benzene, ether or chloroform. "Wang Y, Qing J, Sun Y, et al. Suramin inhibits EV71 infection. Antiviral Res. 2014 Mar;103:1-6. PMID: 24374150. Marques AF, Esser D, Rosenthal PJ, et al. Falcipain-2 inhibition by suramin and suramin analogues. Bioorg Med Chem. 2013 Jul 1;21(13):3667-73. PMID: 23680445. Sakkiah S, Arooj M, Kumar MR, et al. Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations. PLoS One. 2013;8(1):e51429. PMID: 23382805. Erguven M, Akev N, Ozdemir A, et al. The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells. Med Sci Monit. 2008 Aug;14(8):BR165-73. PMID: 18667993. Abbracchio MP, Burnstock G, Boeynaems JM, et al. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 Sep;58(3):281-341. PMID: 16968944. Wolner I, Kassack MU, Ullmann H, et al. Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676. Br J Pharmacol. 2005 Oct;146(4):525-33. PMID: 16056233. Beindl W, Mitterauer T, Hohenegger M, et al. Inhibition of receptor/G protein coupling by suramin analogues. Mol Pharmacol. 1996 Aug;50(2):415-23. PMID: 8700151. " Not dangerous goods. A0817 D,L-1′-Acetoxychavicol Acetate 25 mg 75.3 Found in Languas and Alpinia; TRPA1 agonist, xanthine oxidase inhibitor. Benzenemethanol, 4-(acetyloxy)-α-ethenyl-, acetate "alphaS)-4-(Acetyloxy)-alpha-ethenylbenzenemethanol CCRIS 7708" 52946-22-2 ≥98% 234.25 C13H14O4 CC(=O)OC1=CC=C(C=C1)C(C=C)OC(=O)C 2 years. Ambient Ambient Soluble in DMSO and ethanol. "Williams M, Tietzel I, Quick QA. 1'-Acetoxychavicol acetate promotes caspase 3-activated glioblastoma cell death by overcoming enhanced cytokine expression. Oncol Lett. 2013 Jun;5(6):1968-1972. PMID: 23833677. Seo JW, Cho SC, Park SJ, et al. 1'-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. PLoS One. 2013;8(2):e56447. PMID: 23451048. Aziz AN, Ibrahim H, Rosmy Syamsir D, et al. Antimicrobial compounds from Alpinia conchigera. J Ethnopharmacol. 2013 Feb 13;145(3):798-802. PMID: 23266278. Ohnishi R, Matsui-Yuasa I, Deguchi Y, et al. 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. Am J Chin Med. 2012;40(6):1189-204. PMID: 23227791. In LL, Arshad NM, Ibrahim H, et al. 1'-Acetoxychavicol acetate inhibits growth of human oral carcinoma xenograft in mice and potentiates cisplatin effect via proinflammatory microenvironment alterations. BMC Complement Altern Med. 2012 Oct 9;12:179. PMID: 23043547. Batra V, Syed Z, Gill JN, et al. Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice. J Exp Clin Cancer Res. 2012 Jun 15;31:57. PMID: 22704648. Yaku K, Matsui-Yuasa I, Azuma H, et al. 1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level. Am J Chin Med. 2011;39(4):789-802. PMID: 21721157. Pang X, Zhang L, Lai L, et al. 1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway. Carcinogenesis. 2011 Jun;32(6):904-12. PMID: 21427164. Watanabe K, Takatsuki H, Sonoda M, et al. Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galanga. Drug Discov Ther. 2011 Feb;5(1):26-31. PMID: 22466093. Kaur A, Singh R, Dey CS, et al. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd. Indian J Exp Biol. 2010 Mar;48(3):314-7. PMID: 21046987. Narukawa M, Koizumi K, Iwasaki Y, et al. Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1. Biosci Biotechnol Biochem. 2010;74(8):1694-6. PMID: 20699565. Ichikawa H, Takada Y, Murakami A, et al. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005 Jun 1;174(11):7383-92. PMID: 15905586. " Not dangerous goods. A0817 D,L-1′-Acetoxychavicol Acetate 100 mg 279.1 Found in Languas and Alpinia; TRPA1 agonist, xanthine oxidase inhibitor. Benzenemethanol, 4-(acetyloxy)-α-ethenyl-, acetate "alphaS)-4-(Acetyloxy)-alpha-ethenylbenzenemethanol CCRIS 7708" 52946-22-2 ≥98% 234.25 C13H14O4 CC(=O)OC1=CC=C(C=C1)C(C=C)OC(=O)C 2 years. Ambient Ambient Soluble in DMSO and ethanol. "Williams M, Tietzel I, Quick QA. 1'-Acetoxychavicol acetate promotes caspase 3-activated glioblastoma cell death by overcoming enhanced cytokine expression. Oncol Lett. 2013 Jun;5(6):1968-1972. PMID: 23833677. Seo JW, Cho SC, Park SJ, et al. 1'-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. PLoS One. 2013;8(2):e56447. PMID: 23451048. Aziz AN, Ibrahim H, Rosmy Syamsir D, et al. Antimicrobial compounds from Alpinia conchigera. J Ethnopharmacol. 2013 Feb 13;145(3):798-802. PMID: 23266278. Ohnishi R, Matsui-Yuasa I, Deguchi Y, et al. 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. Am J Chin Med. 2012;40(6):1189-204. PMID: 23227791. In LL, Arshad NM, Ibrahim H, et al. 1'-Acetoxychavicol acetate inhibits growth of human oral carcinoma xenograft in mice and potentiates cisplatin effect via proinflammatory microenvironment alterations. BMC Complement Altern Med. 2012 Oct 9;12:179. PMID: 23043547. Batra V, Syed Z, Gill JN, et al. Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice. J Exp Clin Cancer Res. 2012 Jun 15;31:57. PMID: 22704648. Yaku K, Matsui-Yuasa I, Azuma H, et al. 1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level. Am J Chin Med. 2011;39(4):789-802. PMID: 21721157. Pang X, Zhang L, Lai L, et al. 1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway. Carcinogenesis. 2011 Jun;32(6):904-12. PMID: 21427164. Watanabe K, Takatsuki H, Sonoda M, et al. Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galanga. Drug Discov Ther. 2011 Feb;5(1):26-31. PMID: 22466093. Kaur A, Singh R, Dey CS, et al. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd. Indian J Exp Biol. 2010 Mar;48(3):314-7. PMID: 21046987. Narukawa M, Koizumi K, Iwasaki Y, et al. Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1. Biosci Biotechnol Biochem. 2010;74(8):1694-6. PMID: 20699565. Ichikawa H, Takada Y, Murakami A, et al. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005 Jun 1;174(11):7383-92. PMID: 15905586. " Not dangerous goods. A0817 D,L-1′-Acetoxychavicol Acetate 250 mg 509.7 Found in Languas and Alpinia; TRPA1 agonist, xanthine oxidase inhibitor. Benzenemethanol, 4-(acetyloxy)-α-ethenyl-, acetate "alphaS)-4-(Acetyloxy)-alpha-ethenylbenzenemethanol CCRIS 7708" 52946-22-2 ≥98% 234.25 C13H14O4 CC(=O)OC1=CC=C(C=C1)C(C=C)OC(=O)C 2 years. Ambient Ambient Soluble in DMSO and ethanol. "Williams M, Tietzel I, Quick QA. 1'-Acetoxychavicol acetate promotes caspase 3-activated glioblastoma cell death by overcoming enhanced cytokine expression. Oncol Lett. 2013 Jun;5(6):1968-1972. PMID: 23833677. Seo JW, Cho SC, Park SJ, et al. 1'-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. PLoS One. 2013;8(2):e56447. PMID: 23451048. Aziz AN, Ibrahim H, Rosmy Syamsir D, et al. Antimicrobial compounds from Alpinia conchigera. J Ethnopharmacol. 2013 Feb 13;145(3):798-802. PMID: 23266278. Ohnishi R, Matsui-Yuasa I, Deguchi Y, et al. 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. Am J Chin Med. 2012;40(6):1189-204. PMID: 23227791. In LL, Arshad NM, Ibrahim H, et al. 1'-Acetoxychavicol acetate inhibits growth of human oral carcinoma xenograft in mice and potentiates cisplatin effect via proinflammatory microenvironment alterations. BMC Complement Altern Med. 2012 Oct 9;12:179. PMID: 23043547. Batra V, Syed Z, Gill JN, et al. Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice. J Exp Clin Cancer Res. 2012 Jun 15;31:57. PMID: 22704648. Yaku K, Matsui-Yuasa I, Azuma H, et al. 1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level. Am J Chin Med. 2011;39(4):789-802. PMID: 21721157. Pang X, Zhang L, Lai L, et al. 1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway. Carcinogenesis. 2011 Jun;32(6):904-12. PMID: 21427164. Watanabe K, Takatsuki H, Sonoda M, et al. Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galanga. Drug Discov Ther. 2011 Feb;5(1):26-31. PMID: 22466093. Kaur A, Singh R, Dey CS, et al. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd. Indian J Exp Biol. 2010 Mar;48(3):314-7. PMID: 21046987. Narukawa M, Koizumi K, Iwasaki Y, et al. Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1. Biosci Biotechnol Biochem. 2010;74(8):1694-6. PMID: 20699565. Ichikawa H, Takada Y, Murakami A, et al. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005 Jun 1;174(11):7383-92. PMID: 15905586. " Not dangerous goods. A0819 Acetylsalicylic Acid 500 g 106.8 "NSAID; COX-1/2 inhibitor. " 2-(Acetyloxy)benzoic acid Salicylic acid acetate; aspirin 50-78-2 ≥98% 180.16 C9H8O4 CC(=O)OC1=CC=CC=C1C(=O)O 2 yrs Ambient Ambient Soluble in ethanol (200 mg/mL), DMSO or water (3.3 mg/ml). "Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 2012 May;13(5):518-27. PMID: 22440112. Bartfai T, Conti B. Fever. ScientificWorldJournal. 2010 Mar 16;10:490-503. PMID: 20305990. Antithrombotic Trialists' (ATT) Collaboration: Baigent C, Blackwell L, Collins R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009 May 30;373(9678):1849-60. PMID: 9482214. Tohgi H, Konno S, Tamura K, et al. Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin. Stroke. 1992 Oct;23(10):1400-3. PMID: 1412574. Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485. " T, Xi "UN number: 2811 Class: 6.1 Packing Group: III Proper shipping name: Toxic solid, organic, n.o.s. (Acetylsalicylic Acid)" A0819 Acetylsalicylic Acid 1 kg 131 "NSAID; COX-1/2 inhibitor. " 2-(Acetyloxy)benzoic acid Salicylic acid acetate; aspirin 50-78-2 ≥98% 180.16 C9H8O4 CC(=O)OC1=CC=CC=C1C(=O)O 2 yrs Ambient Ambient Soluble in ethanol (200 mg/mL), DMSO or water (3.3 mg/ml). "Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 2012 May;13(5):518-27. PMID: 22440112. Bartfai T, Conti B. Fever. ScientificWorldJournal. 2010 Mar 16;10:490-503. PMID: 20305990. Antithrombotic Trialists' (ATT) Collaboration: Baigent C, Blackwell L, Collins R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009 May 30;373(9678):1849-60. PMID: 9482214. Tohgi H, Konno S, Tamura K, et al. Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin. Stroke. 1992 Oct;23(10):1400-3. PMID: 1412574. Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485. " T, Xi "UN number: 2811 Class: 6.1 Packing Group: III Proper shipping name: Toxic solid, organic, n.o.s. (Acetylsalicylic Acid)" A0977 Actinomycin 5 mg 95.6 Polypeptide antibiotic produced from Streptomyces; RNA polymerase and topoisomerase inhibitor. Actinomycin D; Meractinomycin; Dactinomycin 50-76-0 ≥98% 1255.5 C62H86N12O16 CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C 2 years at 4oC. Ambient Ambient Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50mg/mL) and methanol (10mg/mL). "Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622. Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596. Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919. " Repr., T+, Carc. "UN number: 3462 Class: 6.1 Packing group: II Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Dactinomycin) Marine pollutant: No Poison inhalation hazard: No" A0977 Actinomycin 10 mg 163 Polypeptide antibiotic produced from Streptomyces; RNA polymerase and topoisomerase inhibitor. Actinomycin D; Meractinomycin; Dactinomycin 50-76-0 ≥98% 1255.5 C62H86N12O16 CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C 2 years at 4oC. Ambient Ambient Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50mg/mL) and methanol (10mg/mL). "Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622. Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596. Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919. " Repr., T+, Carc. "UN number: 3462 Class: 6.1 Packing group: II Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Dactinomycin) Marine pollutant: No Poison inhalation hazard: No" A2044 Aflatoxin B1 1 mg 46.8 Mycotoxin produced by species of Aspergillus; DNA synthesis inhibitor, carcinogen. (6aR-cis)-2,3,6a,9a-Tetrahydro-4-methoxycyclopenta- [c]furo[3',2':4,5]furo[2,3-h][1]-benzopyran-1,11-dione 1162-65-8 ≥98% 312.27 C17H12O6 COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5C=COC5OC4=C1 Avoid light. Ambient 4°C Soluble in ethanol, methylene chloride. "Mili?? NM, Mih?escu G, Chifiriuc C. Aflatoxins--health risk factors. Bacteriol Virusol Parazitol Epidemiol. 2010 Jan-Mar;55(1):19-24. PMID: 21038701. Gabal MA, Hegazi SA, Hassanin N. Aflatoxin production by Aspergillus flavus field isolates. Vet Hum Toxicol. 1994 Dec;36(6):519-21. PMID: 7900269. Dutton MF, Ehrlich K, Bennett JW. Biosynthetic relationship among aflatoxins B1, B2, M1, and M2. Appl Environ Microbiol. 1985 Jun;49(6):1392-5. PMID: 3925881." T+ "UN Number: 3462 Class: 6.1 Packing Group: 1 Toxins, extracted from living sources, solid, n.o.s. (Aflatoxin B1) Reportable quantity (RQ): Marine pollutant: No Poison inhalation hazard: No" A2044 Aflatoxin B1 5 mg 187.4 Mycotoxin produced by species of Aspergillus; DNA synthesis inhibitor, carcinogen. (6aR-cis)-2,3,6a,9a-Tetrahydro-4-methoxycyclopenta- [c]furo[3',2':4,5]furo[2,3-h][1]-benzopyran-1,11-dione 1162-65-8 ≥98% 312.27 C17H12O6 COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5C=COC5OC4=C1 Avoid light. Ambient 4°C Soluble in ethanol, methylene chloride. "Mili?? NM, Mih?escu G, Chifiriuc C. Aflatoxins--health risk factors. Bacteriol Virusol Parazitol Epidemiol. 2010 Jan-Mar;55(1):19-24. PMID: 21038701. Gabal MA, Hegazi SA, Hassanin N. Aflatoxin production by Aspergillus flavus field isolates. Vet Hum Toxicol. 1994 Dec;36(6):519-21. PMID: 7900269. Dutton MF, Ehrlich K, Bennett JW. Biosynthetic relationship among aflatoxins B1, B2, M1, and M2. Appl Environ Microbiol. 1985 Jun;49(6):1392-5. PMID: 3925881." T+ "UN Number: 3462 Class: 6.1 Packing Group: 1 Toxins, extracted from living sources, solid, n.o.s. (Aflatoxin B1) Reportable quantity (RQ): Marine pollutant: No Poison inhalation hazard: No" A4443 L-(+)-Alliin 25 mg 257.7 Optically active cysteine derivative found in Allium. 3-[(S)-2-Propenylsulfinyl]-L-alanine S-Allyl-L-cysteine sulfoxide; 3-(Allylsulfinyl)alanin; Alliin; EINECS 209-118-9; S-Allyl-L-cysteine-S-oxide 556-27-4 ≥98% 177.22 C6H11NO3S C=CCS(=O)CC(C(=O)O)N Ambient -20°C Soluble in water. Insoluble in ethanol, or acetone. PBS to 10 mg/mL. "Ieong Tou W, Chang SS, Wu D, et al. Molecular level activation insights from a NR2A/NR2B agonist. J Biomol Struct Dyn. 2014;32(5):683-93. PMID: 23600691. Quintero-Fabián S, Ortuño-Sahagún D, Vázquez-Carrera M, et al. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators Inflamm. 2013;2013:381815. PMID: 24453416. Nasim SA, Dhir B, Kapoor R, et al. Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats. Pharm Biol. 2011 Apr;49(4):416-21. PMID: 21391887. Sangeetha T, Darlin Quine S. Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol induced cardiotoxicity in male Wistar rats: a histopathological study. Mol Cell Biochem. 2009 Aug;328(1-2):1-8. PMID: 19262997. Mousa AS, Mousa SA. Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutr Cancer. 2005;53(1):104-10. PMID: 16351512. " Xi Not dangerous goods. A4443 L-(+)-Alliin 50 mg 437.4 Optically active cysteine derivative found in Allium. 3-[(S)-2-Propenylsulfinyl]-L-alanine S-Allyl-L-cysteine sulfoxide; 3-(Allylsulfinyl)alanin; Alliin; EINECS 209-118-9; S-Allyl-L-cysteine-S-oxide 556-27-4 ≥98% 177.22 C6H11NO3S C=CCS(=O)CC(C(=O)O)N Ambient -20°C Soluble in water. Insoluble in ethanol, or acetone. PBS to 10 mg/mL. "Ieong Tou W, Chang SS, Wu D, et al. Molecular level activation insights from a NR2A/NR2B agonist. J Biomol Struct Dyn. 2014;32(5):683-93. PMID: 23600691. Quintero-Fabián S, Ortuño-Sahagún D, Vázquez-Carrera M, et al. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators Inflamm. 2013;2013:381815. PMID: 24453416. Nasim SA, Dhir B, Kapoor R, et al. Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats. Pharm Biol. 2011 Apr;49(4):416-21. PMID: 21391887. Sangeetha T, Darlin Quine S. Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol induced cardiotoxicity in male Wistar rats: a histopathological study. Mol Cell Biochem. 2009 Aug;328(1-2):1-8. PMID: 19262997. Mousa AS, Mousa SA. Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutr Cancer. 2005;53(1):104-10. PMID: 16351512. " Xi Not dangerous goods. A4443 L-(+)-Alliin 100 mg 783 Optically active cysteine derivative found in Allium. 3-[(S)-2-Propenylsulfinyl]-L-alanine S-Allyl-L-cysteine sulfoxide; 3-(Allylsulfinyl)alanin; Alliin; EINECS 209-118-9; S-Allyl-L-cysteine-S-oxide 556-27-4 ≥98% 177.22 C6H11NO3S C=CCS(=O)CC(C(=O)O)N Ambient -20°C Soluble in water. Insoluble in ethanol, or acetone. PBS to 10 mg/mL. "Ieong Tou W, Chang SS, Wu D, et al. Molecular level activation insights from a NR2A/NR2B agonist. J Biomol Struct Dyn. 2014;32(5):683-93. PMID: 23600691. Quintero-Fabián S, Ortuño-Sahagún D, Vázquez-Carrera M, et al. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators Inflamm. 2013;2013:381815. PMID: 24453416. Nasim SA, Dhir B, Kapoor R, et al. Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats. Pharm Biol. 2011 Apr;49(4):416-21. PMID: 21391887. Sangeetha T, Darlin Quine S. Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol induced cardiotoxicity in male Wistar rats: a histopathological study. Mol Cell Biochem. 2009 Aug;328(1-2):1-8. PMID: 19262997. Mousa AS, Mousa SA. Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutr Cancer. 2005;53(1):104-10. PMID: 16351512. " Xi Not dangerous goods. A4445 Allopurinol 5 g 26.4 Purine (hypoxanthine) analog; xanthine oxidase inhibitor. 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Adenock; Apurol; Allozym; Apurin; Bloxanth; Embarin; Gichtex; Ketanrift; Lysuron; Urosin; Zyloric 315-30-0 ≥98% 136.11 C5H4N4O C1=C2C(=NC=NC2=O)NN1 Ambient Ambient Soluble in Methanol and DMSO. Slightly soluble in ethanol (0.30 mg/ml) and water (0.48 mg/ml). "Prieto-Moure B, Carabén-Redaño A, Aliena-Valero A, et al. Allopurinol in renal ischemia. J Invest Surg. 2014 Oct;27(5):304-16. PMID: 24914485. Essawy SS, Elbaz AA. Role of adenosine receptors in the anti-nociceptive effects of allopurinol in mice. Eur Rev Med Pharmacol Sci. 2013 Jul;17(14):1857-63. PMID: 23877847. Sakabe M, Fujiki A, Sakamoto T, et al. Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction. J Cardiovasc Electrophysiol. 2012 Oct;23(10):1130-5. PMID: 22587612. Pacher P, Nivorozhkin A, Szabó C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. PMID: 16507884. " T, Xi, Xn "UN number: 2811 Class: 6.1 Packing group: III Proper shipping name: Toxic solid, organic, n.o.s. (Allopurinol) Marine pollutant: No Poison inhalation hazard: No" A4445 Allopurinol 10 g 47.8 Purine (hypoxanthine) analog; xanthine oxidase inhibitor. 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Adenock; Apurol; Allozym; Apurin; Bloxanth; Embarin; Gichtex; Ketanrift; Lysuron; Urosin; Zyloric 315-30-0 ≥98% 136.11 C5H4N4O C1=C2C(=NC=NC2=O)NN1 Ambient Ambient Soluble in Methanol and DMSO. Slightly soluble in ethanol (0.30 mg/ml) and water (0.48 mg/ml). "Prieto-Moure B, Carabén-Redaño A, Aliena-Valero A, et al. Allopurinol in renal ischemia. J Invest Surg. 2014 Oct;27(5):304-16. PMID: 24914485. Essawy SS, Elbaz AA. Role of adenosine receptors in the anti-nociceptive effects of allopurinol in mice. Eur Rev Med Pharmacol Sci. 2013 Jul;17(14):1857-63. PMID: 23877847. Sakabe M, Fujiki A, Sakamoto T, et al. Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction. J Cardiovasc Electrophysiol. 2012 Oct;23(10):1130-5. PMID: 22587612. Pacher P, Nivorozhkin A, Szabó C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. PMID: 16507884. " T, Xi, Xn "UN number: 2811 Class: 6.1 Packing group: III Proper shipping name: Toxic solid, organic, n.o.s. (Allopurinol) Marine pollutant: No Poison inhalation hazard: No" A4544 Allyl Disulfide 500 mg 117.8 Organosulfur found in garlic. Diallyl disulfide 2-Propenyl disulfide; 2-Propenyl disulphide; 4,5-Dithia-1,7-octadiene; AI3-35128; Allyl disulphide; BRN 1699241; CCRIS 6290; Di(2-propenyl) disulfide; Diallyl disulphide; Disulfide, di-2-propenyl 2179-57-9 ≥98% 146.28 C6H10S2 C=CCSSCC=C Ambient -20°C Soluble in ethanol (3 mg/mL) and oil. Insoluble in water. DMSO to 5 mg/mL. DMF to 10 mg/mL. Chloroform, methanol. "Schelkle B, Snellgrove D, Cable J. In vitro and in vivo efficacy of garlic compounds against Gyrodactylus turnbulli infecting the guppy (Poecilia reticulata). Vet Parasitol. 2013 Nov 15;198(1-2):96-101. PMID: 24074607. Dasgupta P, Bandyopadhyay SS. Role of di-allyl disulfide, a garlic component in NF-κB mediated transient G2-M phase arrest and apoptosis in human leukemic cell-lines. Nutr Cancer. 2013;65(4):611-22. PMID: 23659453. Trinh K, Moore K, Wes PD, et al. Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. J Neurosci. 2008 Jan 9;28(2):465-72. PMID: 18184789. Chung LY. The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food. 2006 Summer;9(2):205-13. PMID: 16822206. Singh DK, Porter TD. Inhibition of sterol 4alpha-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. J Nutr. 2006 Mar;136(3 Suppl):759S-764S. PMID: 16484558. Shoji S, Furuishi K, Yanase R, et al. Allyl compounds selectively killed human immunodeficiency virus (type 1)-infected cells. Biochem Biophys Res Commun. 1993 Jul 30;194(2):610-21. PMID: 8343148. " Xn, Xi "UN number: 1992 Class: 3 Packing group: III Proper shipping name: Flammable liquid, Toxic, n.o.s. (Diallyl disulfide) Reportable quantity (RQ): Marine pollutant: No; Poison inhalation hazard: No" A4544 Allyl Disulfide 1 g 222.9 Organosulfur found in garlic. Diallyl disulfide 2-Propenyl disulfide; 2-Propenyl disulphide; 4,5-Dithia-1,7-octadiene; AI3-35128; Allyl disulphide; BRN 1699241; CCRIS 6290; Di(2-propenyl) disulfide; Diallyl disulphide; Disulfide, di-2-propenyl 2179-57-9 ≥98% 146.28 C6H10S2 C=CCSSCC=C Ambient -20°C Soluble in ethanol (3 mg/mL) and oil. Insoluble in water. DMSO to 5 mg/mL. DMF to 10 mg/mL. Chloroform, methanol. "Schelkle B, Snellgrove D, Cable J. In vitro and in vivo efficacy of garlic compounds against Gyrodactylus turnbulli infecting the guppy (Poecilia reticulata). Vet Parasitol. 2013 Nov 15;198(1-2):96-101. PMID: 24074607. Dasgupta P, Bandyopadhyay SS. Role of di-allyl disulfide, a garlic component in NF-κB mediated transient G2-M phase arrest and apoptosis in human leukemic cell-lines. Nutr Cancer. 2013;65(4):611-22. PMID: 23659453. Trinh K, Moore K, Wes PD, et al. Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. J Neurosci. 2008 Jan 9;28(2):465-72. PMID: 18184789. Chung LY. The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food. 2006 Summer;9(2):205-13. PMID: 16822206. Singh DK, Porter TD. Inhibition of sterol 4alpha-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. J Nutr. 2006 Mar;136(3 Suppl):759S-764S. PMID: 16484558. Shoji S, Furuishi K, Yanase R, et al. Allyl compounds selectively killed human immunodeficiency virus (type 1)-infected cells. Biochem Biophys Res Commun. 1993 Jul 30;194(2):610-21. PMID: 8343148. " Xn, Xi "UN number: 1992 Class: 3 Packing group: III Proper shipping name: Flammable liquid, Toxic, n.o.s. (Diallyl disulfide) Reportable quantity (RQ): Marine pollutant: No; Poison inhalation hazard: No" A4544 Allyl Disulfide 5 g 837.2 Organosulfur found in garlic. Diallyl disulfide 2-Propenyl disulfide; 2-Propenyl disulphide; 4,5-Dithia-1,7-octadiene; AI3-35128; Allyl disulphide; BRN 1699241; CCRIS 6290; Di(2-propenyl) disulfide; Diallyl disulphide; Disulfide, di-2-propenyl 2179-57-9 ≥98% 146.28 C6H10S2 C=CCSSCC=C Ambient -20°C Soluble in ethanol (3 mg/mL) and oil. Insoluble in water. DMSO to 5 mg/mL. DMF to 10 mg/mL. Chloroform, methanol. "Schelkle B, Snellgrove D, Cable J. In vitro and in vivo efficacy of garlic compounds against Gyrodactylus turnbulli infecting the guppy (Poecilia reticulata). Vet Parasitol. 2013 Nov 15;198(1-2):96-101. PMID: 24074607. Dasgupta P, Bandyopadhyay SS. Role of di-allyl disulfide, a garlic component in NF-κB mediated transient G2-M phase arrest and apoptosis in human leukemic cell-lines. Nutr Cancer. 2013;65(4):611-22. PMID: 23659453. Trinh K, Moore K, Wes PD, et al. Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. J Neurosci. 2008 Jan 9;28(2):465-72. PMID: 18184789. Chung LY. The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food. 2006 Summer;9(2):205-13. PMID: 16822206. Singh DK, Porter TD. Inhibition of sterol 4alpha-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. J Nutr. 2006 Mar;136(3 Suppl):759S-764S. PMID: 16484558. Shoji S, Furuishi K, Yanase R, et al. Allyl compounds selectively killed human immunodeficiency virus (type 1)-infected cells. Biochem Biophys Res Commun. 1993 Jul 30;194(2):610-21. PMID: 8343148. " Xn, Xi "UN number: 1992 Class: 3 Packing group: III Proper shipping name: Flammable liquid, Toxic, n.o.s. (Diallyl disulfide) Reportable quantity (RQ): Marine pollutant: No; Poison inhalation hazard: No" A4496 Alyssin 25 mg 155.4 Naturally sourced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-5-(methylsulfinyl)pentane; 5-methylsulfinylpentyl isothiocyanate 646-23-1 ≥97% 191.32 C7H13NOS2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in water, DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, et al. Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):18-28. PMID: 19202560. " Not dangerous goods. A4496 Alyssin 50 mg 278.3 Naturally sourced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-5-(methylsulfinyl)pentane; 5-methylsulfinylpentyl isothiocyanate 646-23-1 ≥97% 191.32 C7H13NOS2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in water, DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, et al. Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):18-28. PMID: 19202560. " Not dangerous goods. A4496 Alyssin 100 mg 493.5 Naturally sourced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-5-(methylsulfinyl)pentane; 5-methylsulfinylpentyl isothiocyanate 646-23-1 ≥97% 191.32 C7H13NOS2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in water, DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, et al. Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):18-28. PMID: 19202560. " Not dangerous goods. A4496 Alyssin 500 mg 1575 Naturally sourced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-5-(methylsulfinyl)pentane; 5-methylsulfinylpentyl isothiocyanate 646-23-1 ≥97% 191.32 C7H13NOS2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in water, DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, et al. Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):18-28. PMID: 19202560. " Not dangerous goods. A4497 Alyssin Sulfone 25 mg 155.4 Naturally sourced ITC, sulfonyl analog of sulforaphane. ≥97% 207.31 C7H13NO2S2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. " Not dangerous goods. A4497 Alyssin Sulfone 50 mg 260.4 Naturally sourced ITC, sulfonyl analog of sulforaphane. ≥97% 207.31 C7H13NO2S2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. " Not dangerous goods. A4497 Alyssin Sulfone 100 mg 456.8 Naturally sourced ITC, sulfonyl analog of sulforaphane. ≥97% 207.31 C7H13NO2S2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. " Not dangerous goods. A4497 Alyssin Sulfone 500 mg 1575 Naturally sourced ITC, sulfonyl analog of sulforaphane. ≥97% 207.31 C7H13NO2S2 CS(=O)CCCCCN=C=S >3 yrs. at -20°C Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. " Not dangerous goods. A5030 4-Aminophenylphosphate Monosodium 10 mg 75.8 Alkaline phosphatase substrate used to quantify enzyme activity. 4-aminobenzenephosphoric sodium 52331-30-3 ≥97% 211.09 C6H7NO4PNa C1=CC(=CC=C1N)P(=O)([O-])[O-] Ambient -20°C Soluble in methanol and water. "Akanda MR, Tamilavan V, Park S, et al. Hydroquinone diphosphate as a phosphatase substrate in enzymatic amplification combined with electrochemical-chemical-chemical redox cycling for the detection of E. coli O157:H7. Anal Chem. 2013 Feb 5;85(3):1631-6. PMID: 23327094. Pemberton RM, Hart JP, Stoddard P, et al. A comparison of 1-naphthyl phosphate and 4 aminophenyl phosphate as enzyme substrates for use with a screen-printed amperometric immunosensor for progesterone in cows' milk. Biosens Bioelectron. 1999 May 31;14(5):495-503. PMID: 10451917. Xiang Y, Zhang Y, Qian X, et al. Ultrasensitive aptamer-based protein detection via a dual amplified biocatalytic strategy. Biosens Bioelectron. 2010 Jul 15;25(11):2539-2542. PMID: 20452761. " Not dangerous goods. A5030 4-Aminophenylphosphate Monosodium 50 mg 261.5 Alkaline phosphatase substrate used to quantify enzyme activity. 4-aminobenzenephosphoric sodium 52331-30-3 ≥97% 211.09 C6H7NO4PNa C1=CC(=CC=C1N)P(=O)([O-])[O-] Ambient -20°C Soluble in methanol and water. "Akanda MR, Tamilavan V, Park S, et al. Hydroquinone diphosphate as a phosphatase substrate in enzymatic amplification combined with electrochemical-chemical-chemical redox cycling for the detection of E. coli O157:H7. Anal Chem. 2013 Feb 5;85(3):1631-6. PMID: 23327094. Pemberton RM, Hart JP, Stoddard P, et al. A comparison of 1-naphthyl phosphate and 4 aminophenyl phosphate as enzyme substrates for use with a screen-printed amperometric immunosensor for progesterone in cows' milk. Biosens Bioelectron. 1999 May 31;14(5):495-503. PMID: 10451917. Xiang Y, Zhang Y, Qian X, et al. Ultrasensitive aptamer-based protein detection via a dual amplified biocatalytic strategy. Biosens Bioelectron. 2010 Jul 15;25(11):2539-2542. PMID: 20452761. " Not dangerous goods. A5030 4-Aminophenylphosphate Monosodium 100 mg 479.3 Alkaline phosphatase substrate used to quantify enzyme activity. 4-aminobenzenephosphoric sodium 52331-30-3 ≥97% 211.09 C6H7NO4PNa C1=CC(=CC=C1N)P(=O)([O-])[O-] Ambient -20°C Soluble in methanol and water. "Akanda MR, Tamilavan V, Park S, et al. Hydroquinone diphosphate as a phosphatase substrate in enzymatic amplification combined with electrochemical-chemical-chemical redox cycling for the detection of E. coli O157:H7. Anal Chem. 2013 Feb 5;85(3):1631-6. PMID: 23327094. Pemberton RM, Hart JP, Stoddard P, et al. A comparison of 1-naphthyl phosphate and 4 aminophenyl phosphate as enzyme substrates for use with a screen-printed amperometric immunosensor for progesterone in cows' milk. Biosens Bioelectron. 1999 May 31;14(5):495-503. PMID: 10451917. Xiang Y, Zhang Y, Qian X, et al. Ultrasensitive aptamer-based protein detection via a dual amplified biocatalytic strategy. Biosens Bioelectron. 2010 Jul 15;25(11):2539-2542. PMID: 20452761. " Not dangerous goods. A5217 trans-Anethole 50 ml 88.1 Phenylpropene derivative found in essential oils; NMDA agonist. 1-Methoxy-4-(1E)-1-propenylbenzene trans-p-Propenylanisole; Anise camphor; Isoestragole; Monasirup 4180-23-8 ≥98% 148.2 C10H12O CC=CC1=CC=C(C=C1)OC Ambient Ambient Soluble in benzene, ethyl acetate, acetone, carbon disulfide, or petr ether. Ethanol (500 mg/mL). "Miyagawa M, Satou T, Yukimune C, et al. Anxiolytic-Like Effect of Illicium verum Fruit Oil, trans-Anethole and Related Compounds in Mice. Phytother Res. 2014 Jun 11. [Epub ahead of print]. PMID: 24919985. Ryu S, Seol GH, Park H, et al. Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation. Neurol Sci. 2014 Oct;35(10):1541-7. PMID: 24777545. Fujita KI, Tatsumi M, Ogita A, et al. Anethole induces apoptotic cell death accompanied by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae. FEBS J. 2014 Jan 2. [Epub ahead of print]. PMID: 24393541. Cho HI, Kim KM, Kwak JH, et al. Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice. J Nat Prod. 2013 Sep 27;76(9):1717-23. PMID: 23962021. " Xi Not dangerous goods. A5217 trans-Anethole 100 ml 152 Phenylpropene derivative found in essential oils; NMDA agonist. 1-Methoxy-4-(1E)-1-propenylbenzene trans-p-Propenylanisole; Anise camphor; Isoestragole; Monasirup 4180-23-8 ≥98% 148.2 C10H12O CC=CC1=CC=C(C=C1)OC Ambient Ambient Soluble in benzene, ethyl acetate, acetone, carbon disulfide, or petr ether. Ethanol (500 mg/mL). "Miyagawa M, Satou T, Yukimune C, et al. Anxiolytic-Like Effect of Illicium verum Fruit Oil, trans-Anethole and Related Compounds in Mice. Phytother Res. 2014 Jun 11. [Epub ahead of print]. PMID: 24919985. Ryu S, Seol GH, Park H, et al. Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation. Neurol Sci. 2014 Oct;35(10):1541-7. PMID: 24777545. Fujita KI, Tatsumi M, Ogita A, et al. Anethole induces apoptotic cell death accompanied by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae. FEBS J. 2014 Jan 2. [Epub ahead of print]. PMID: 24393541. Cho HI, Kim KM, Kwak JH, et al. Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice. J Nat Prod. 2013 Sep 27;76(9):1717-23. PMID: 23962021. " Xi Not dangerous goods. A1865 Aeroplysinin 100 µg 40.4 Marine sponge alkaloid. 3,5-dibromo-1,5-dihydroxy-4-methoxy-2,4-cyclo- hexadiene-1-acetonitrile "(1S-trans)-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1- acetonitrile" 28656-91-9 ≥96% 338.98 C9H9Br2NO3 COC1=C(C(C(C=C1Br)(CC#N)O)O)Br Ambient -20°C Soluble in DMSO or ethanol. "Martínez-Poveda B, García-Vilas JA, Cárdenas C, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203. PMID: 23383109. Rodríguez-Nieto S, González-Iriarte M, Carmona R, et al. Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge. FASEB J. 2002 Feb;16(2):261-3. PMID: 11772945. Koulman A, Proksch P, Ebel R, et al. Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba. J Nat Prod. 1996 Jun;59(6):591-4. PMID: 8786366. " Not dangerous goods. A1865 Aeroplysinin 5 x 100 µg 138.7 Marine sponge alkaloid. 3,5-dibromo-1,5-dihydroxy-4-methoxy-2,4-cyclo- hexadiene-1-acetonitrile "(1S-trans)-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1- acetonitrile" 28656-91-9 ≥96% 338.98 C9H9Br2NO3 COC1=C(C(C(C=C1Br)(CC#N)O)O)Br Ambient -20°C Soluble in DMSO or ethanol. "Martínez-Poveda B, García-Vilas JA, Cárdenas C, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203. PMID: 23383109. Rodríguez-Nieto S, González-Iriarte M, Carmona R, et al. Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge. FASEB J. 2002 Feb;16(2):261-3. PMID: 11772945. Koulman A, Proksch P, Ebel R, et al. Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba. J Nat Prod. 1996 Jun;59(6):591-4. PMID: 8786366. " Not dangerous goods. A1865 Aeroplysinin 1 mg 231.1 Marine sponge alkaloid. 3,5-dibromo-1,5-dihydroxy-4-methoxy-2,4-cyclo- hexadiene-1-acetonitrile "(1S-trans)-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1- acetonitrile" 28656-91-9 ≥96% 338.98 C9H9Br2NO3 COC1=C(C(C(C=C1Br)(CC#N)O)O)Br Ambient -20°C Soluble in DMSO or ethanol. "Martínez-Poveda B, García-Vilas JA, Cárdenas C, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203. PMID: 23383109. Rodríguez-Nieto S, González-Iriarte M, Carmona R, et al. Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge. FASEB J. 2002 Feb;16(2):261-3. PMID: 11772945. Koulman A, Proksch P, Ebel R, et al. Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba. J Nat Prod. 1996 Jun;59(6):591-4. PMID: 8786366. " Not dangerous goods. A6978 Artemisinin 100 mg 47.6 Sesquiterpene lactone found in Artemisia (wormwood). (3R,S,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-tri- methyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzo- dioxepin-10(3H)-one Artemisine; Arteannuin; Quinghaosu; QHS 63968-64-9 ≥98% 282.35 C15H22O5 CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C Ambient Ambient Insoluble in water. Soluble in DMSO, acetone, ethanol, or chloroform "Gu Y, Wu G, Wang X, et al. Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43. Mol Med Rep. 2014 Oct;10(4):1851-6. PMID: 25110145. Tan WQ, Chen G, Jia B, et al. Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling. Pharmazie. 2014 Jun;69(6):468-72. PMID: 24974584. Patel K, Batty KT, Moore BR, et al. Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model. J Antimicrob Chemother. 2014 Aug;69(8):2155-63. PMID: 24777899. Yu WY, Kan WJ, Yu PX, et al. Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2618-21. PMID: 23236763." None Not dangerous goods. A6978 Artemisinin 500 mg 163 Sesquiterpene lactone found in Artemisia (wormwood). (3R,S,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-tri- methyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzo- dioxepin-10(3H)-one Artemisine; Arteannuin; Quinghaosu; QHS 63968-64-9 ≥98% 282.35 C15H22O5 CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C Ambient Ambient Insoluble in water. Soluble in DMSO, acetone, ethanol, or chloroform "Gu Y, Wu G, Wang X, et al. Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43. Mol Med Rep. 2014 Oct;10(4):1851-6. PMID: 25110145. Tan WQ, Chen G, Jia B, et al. Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling. Pharmazie. 2014 Jun;69(6):468-72. PMID: 24974584. Patel K, Batty KT, Moore BR, et al. Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model. J Antimicrob Chemother. 2014 Aug;69(8):2155-63. PMID: 24777899. Yu WY, Kan WJ, Yu PX, et al. Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2618-21. PMID: 23236763." None Not dangerous goods. A6978 Artemisinin 1 g 247.2 Sesquiterpene lactone found in Artemisia (wormwood). (3R,S,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-tri- methyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzo- dioxepin-10(3H)-one Artemisine; Arteannuin; Quinghaosu; QHS 63968-64-9 ≥98% 282.35 C15H22O5 CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C Ambient Ambient Insoluble in water. Soluble in DMSO, acetone, ethanol, or chloroform "Gu Y, Wu G, Wang X, et al. Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43. Mol Med Rep. 2014 Oct;10(4):1851-6. PMID: 25110145. Tan WQ, Chen G, Jia B, et al. Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling. Pharmazie. 2014 Jun;69(6):468-72. PMID: 24974584. Patel K, Batty KT, Moore BR, et al. Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model. J Antimicrob Chemother. 2014 Aug;69(8):2155-63. PMID: 24777899. Yu WY, Kan WJ, Yu PX, et al. Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2618-21. PMID: 23236763." None Not dangerous goods. A7309 Ascorbyl Palmitate 25 g 51 Fat-soluble vitamin C derivative. L-Ascorbic acid, 6-palmitate Ascorbic acid palmitate; Ascorbic palmitate; Quicifal; Ondascora; Vitamin C palmitate; 6-Palmitoylascorbic acid 137-66-6 ≥95% 414.53 C22H38O7 CCCCCCCCCCCCCCCC(=O)OCC(C1C(=C(C(=O)O1)O)O)O Ambient Ambient Insoluble in water. Ethanol (8 mg/mL) "Zariwala MG, Farnaud S, Merchant Z, et al. Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: preparation, characterisation and in vitro evaluation. Colloids Surf B Biointerfaces. 2014 Mar 1;115:86-92. PMID: 24333557. Let MB, Jacobsen C, Meyer AS. Ascorbyl palmitate, gamma-tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently. J Agric Food Chem. 2007 Mar 21;55(6):2369-75. PMID: 17319681. Llabot JM, Palma SD, Manzo RH, et al. Design of novel antifungal mucoadhesive films. Part II. Formulation and in vitro biopharmaceutical evaluation. Int J Pharm. 2007 May 24;336(2):263-8. PMID: 17223291. Jurkovic P, Sentjurc M, Gasperlin M, et al. Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions. Eur J Pharm Biopharm. 2003 Jul;56(1):59-66. PMID: 12837482. " None Not dangerous goods. A7309 Ascorbyl Palmitate 100 g 138.8 Fat-soluble vitamin C derivative. L-Ascorbic acid, 6-palmitate Ascorbic acid palmitate; Ascorbic palmitate; Quicifal; Ondascora; Vitamin C palmitate; 6-Palmitoylascorbic acid 137-66-6 ≥95% 414.53 C22H38O7 CCCCCCCCCCCCCCCC(=O)OCC(C1C(=C(C(=O)O1)O)O)O Ambient Ambient Insoluble in water. Ethanol (8 mg/mL) "Zariwala MG, Farnaud S, Merchant Z, et al. Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: preparation, characterisation and in vitro evaluation. Colloids Surf B Biointerfaces. 2014 Mar 1;115:86-92. PMID: 24333557. Let MB, Jacobsen C, Meyer AS. Ascorbyl palmitate, gamma-tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently. J Agric Food Chem. 2007 Mar 21;55(6):2369-75. PMID: 17319681. Llabot JM, Palma SD, Manzo RH, et al. Design of novel antifungal mucoadhesive films. Part II. Formulation and in vitro biopharmaceutical evaluation. Int J Pharm. 2007 May 24;336(2):263-8. PMID: 17223291. Jurkovic P, Sentjurc M, Gasperlin M, et al. Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions. Eur J Pharm Biopharm. 2003 Jul;56(1):59-66. PMID: 12837482. " None Not dangerous goods. A7309 Ascorbyl Palmitate 500 g 370.3 Fat-soluble vitamin C derivative. L-Ascorbic acid, 6-palmitate Ascorbic acid palmitate; Ascorbic palmitate; Quicifal; Ondascora; Vitamin C palmitate; 6-Palmitoylascorbic acid 137-66-6 ≥95% 414.53 C22H38O7 CCCCCCCCCCCCCCCC(=O)OCC(C1C(=C(C(=O)O1)O)O)O Ambient Ambient Insoluble in water. Ethanol (8 mg/mL) "Zariwala MG, Farnaud S, Merchant Z, et al. Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: preparation, characterisation and in vitro evaluation. Colloids Surf B Biointerfaces. 2014 Mar 1;115:86-92. PMID: 24333557. Let MB, Jacobsen C, Meyer AS. Ascorbyl palmitate, gamma-tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently. J Agric Food Chem. 2007 Mar 21;55(6):2369-75. PMID: 17319681. Llabot JM, Palma SD, Manzo RH, et al. Design of novel antifungal mucoadhesive films. Part II. Formulation and in vitro biopharmaceutical evaluation. Int J Pharm. 2007 May 24;336(2):263-8. PMID: 17223291. Jurkovic P, Sentjurc M, Gasperlin M, et al. Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions. Eur J Pharm Biopharm. 2003 Jul;56(1):59-66. PMID: 12837482. " None Not dangerous goods. B1652 Benzo[a]pyrene 500 mg 156.2 Polycyclic aromatic hydrocarbon (PAH) found in coal tar, cigarette smoke, and wood smoke; carcinogen. 3,4-Benzpyrene 1,2-benzpyrene; 1,2-benzopyrene, 6,7-benzopyrene; benzo[a]pyrene; BP; 3,4-benzylpyrene; 3,4-benz[a]pyrene 50-32-8 ≥98% 252.32 C20H12 C1=CC=C2C3=C4C(=CC2=C1)C=CC5=C4C(=CC=C5)C=C3 Ambient Ambient Soluble in chloroform, benzene, toluene, xylene and ether. Insoluble in water. "Gao L, Mai A, Li X, et al. LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene. Toxicol Lett. 2013 Nov 25;223(2):205-10. PMID: 24084393. Naveenkumar C, Raghunandakumar S, Asokkumar S, et al. Mitigating role of baicalein on lysosomal enzymes and xenobiotic metabolizing enzyme status during lung carcinogenesis of Swiss albino mice induced by benzo(a)pyrene. Fundam Clin Pharmacol. 2014 Jun;28(3):310-22. PMID: 23834621. Poirier MC, Santella R, Weinstein IB, et al. Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay. Cancer Res. 1980 Feb;40(2):412-6. PMID: 7356524. Selkirk JK. Benzo[a]pyrene carcinogenesis: a biochemical selection mechanism. J Toxicol Environ Health. 1977 Jul;2(6):1245-58. PMID: 328915." T,N "UN number: 3077 Class: 9 Packing group: III Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Benzo[a]pyrene) Reportable Quantity (RQ): 1lbs. Marine pollutant: Poison inhalation hazard: No" B1652 Benzo[a]pyrene 1 g 271.7 Polycyclic aromatic hydrocarbon (PAH) found in coal tar, cigarette smoke, and wood smoke; carcinogen. 3,4-Benzpyrene 1,2-benzpyrene; 1,2-benzopyrene, 6,7-benzopyrene; benzo[a]pyrene; BP; 3,4-benzylpyrene; 3,4-benz[a]pyrene 50-32-8 ≥98% 252.32 C20H12 C1=CC=C2C3=C4C(=CC2=C1)C=CC5=C4C(=CC=C5)C=C3 Ambient Ambient Soluble in chloroform, benzene, toluene, xylene and ether. Insoluble in water. "Gao L, Mai A, Li X, et al. LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene. Toxicol Lett. 2013 Nov 25;223(2):205-10. PMID: 24084393. Naveenkumar C, Raghunandakumar S, Asokkumar S, et al. Mitigating role of baicalein on lysosomal enzymes and xenobiotic metabolizing enzyme status during lung carcinogenesis of Swiss albino mice induced by benzo(a)pyrene. Fundam Clin Pharmacol. 2014 Jun;28(3):310-22. PMID: 23834621. Poirier MC, Santella R, Weinstein IB, et al. Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay. Cancer Res. 1980 Feb;40(2):412-6. PMID: 7356524. Selkirk JK. Benzo[a]pyrene carcinogenesis: a biochemical selection mechanism. J Toxicol Environ Health. 1977 Jul;2(6):1245-58. PMID: 328915." T,N "UN number: 3077 Class: 9 Packing group: III Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Benzo[a]pyrene) Reportable Quantity (RQ): 1lbs. Marine pollutant: Poison inhalation hazard: No" B1653 Benzyl Isothiocyanate 5 g 41.6 ITC found in cruciferous vegetables. Benzene, (isothiocyanatomethyl)- Isothiocyanic acid benzyl ester; 2-Bromo-4-trifluoro- methyl-6-nitrophenyl-isothiocyanate 622-78-6 ≥97% 149.22 C8H7NS C1=CC=C(C=C1)CN=C=S Ambient 4°C Soluble in DMSO, ethanol, or chloroform. "Tang Y, Abe N, Yoshimoto M, et al. Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells. Biosci Biotechnol Biochem. 2014 Sep 25:1-5. PMID: 25253661. Kim M, Cho HJ, Kwon GT, et al. Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity-resistant BALB/c mice. Mol Carcinog. 2014 Apr 11. [Epub ahead of print]. PMID: 24729546. Steverding D, Michaels S, Read KD. In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates. Planta Med. 2014 Feb;80(2-3):183-6. PMID: 24452460. Dufour V, Stahl M, Rosenfeld E, et al. Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni. Appl Environ Microbiol. 2013 Nov;79(22):6958-68. PMID: 24014524. Huang CS, Lin AH, Liu CT, et al. Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation. Mol Nutr Food Res. 2013 Nov;57(11):1918-30. PMID: 23836589. Lin JF, Tsai TF, Liao PC, et al. Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling. Carcinogenesis. 2013 Feb;34(2):406-14. PMID: 23172666. Boreddy SR, Sahu RP, Srivastava SK. Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS One. 2011;6(10):e25799. PMID: 22016776. Warin R, Chambers WH, Potter DM, et al. Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate. Cancer Res. 2009 Dec 15;69(24):9473-80. PMID: 19934325. Kim SH, Nagalingam A, Saxena NK, et al. Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. Carcinogenesis. 2011 Mar;32(3):359-367. PMID: 21163886. " Xn, Xi "UN number: 3334 Class: 9 Proper shipping name: A aviation regulated liquid, n.o.s. (Benzyl isothiocyanate) Marine pollutant: No, Poison inhalation hazard: No" B1653 Benzyl Isothiocyanate 10 g 73.9 ITC found in cruciferous vegetables. Benzene, (isothiocyanatomethyl)- Isothiocyanic acid benzyl ester; 2-Bromo-4-trifluoro- methyl-6-nitrophenyl-isothiocyanate 622-78-6 ≥97% 149.22 C8H7NS C1=CC=C(C=C1)CN=C=S Ambient 4°C Soluble in DMSO, ethanol, or chloroform. "Tang Y, Abe N, Yoshimoto M, et al. Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells. Biosci Biotechnol Biochem. 2014 Sep 25:1-5. PMID: 25253661. Kim M, Cho HJ, Kwon GT, et al. Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity-resistant BALB/c mice. Mol Carcinog. 2014 Apr 11. [Epub ahead of print]. PMID: 24729546. Steverding D, Michaels S, Read KD. In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates. Planta Med. 2014 Feb;80(2-3):183-6. PMID: 24452460. Dufour V, Stahl M, Rosenfeld E, et al. Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni. Appl Environ Microbiol. 2013 Nov;79(22):6958-68. PMID: 24014524. Huang CS, Lin AH, Liu CT, et al. Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation. Mol Nutr Food Res. 2013 Nov;57(11):1918-30. PMID: 23836589. Lin JF, Tsai TF, Liao PC, et al. Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling. Carcinogenesis. 2013 Feb;34(2):406-14. PMID: 23172666. Boreddy SR, Sahu RP, Srivastava SK. Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS One. 2011;6(10):e25799. PMID: 22016776. Warin R, Chambers WH, Potter DM, et al. Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate. Cancer Res. 2009 Dec 15;69(24):9473-80. PMID: 19934325. Kim SH, Nagalingam A, Saxena NK, et al. Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. Carcinogenesis. 2011 Mar;32(3):359-367. PMID: 21163886. " Xn, Xi "UN number: 3334 Class: 9 Proper shipping name: A aviation regulated liquid, n.o.s. (Benzyl isothiocyanate) Marine pollutant: No, Poison inhalation hazard: No" B1654 Benzyl Selenocyanate 50 mg 84.3 Organoselenium compound found in selenium-enriched garlic; potential PKA and PKC inhibitor. "Benzyl selenocyanate " Selenocyanic acid; benzyl ester; Selenocyanic acid; phenylmethyl ester (9CI) 4671-93-6 ≥98% 196.11 C8H7NSe C1=CC=C(C=C1)C[Se]C#N Ambient 4°C "El-Bayoumy K, Sinha R, Pinto JT, et al. Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. J Nutr. 2006 Mar;136(3 Suppl):864S-869S. PMID: 16484582. Fiala ES, Staretz ME, Pandya GA, et al. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis. 1998 Apr;19(4):597-604. PMID: 9600343. Foiles P, Fujiki H, Suganuma M, et al. Inhibition of pkc and pka by chemopreventive organoselenium compounds. Int J Oncol. 1995 Sep;7(3):685-90. PMID: 21552892. " B1654 Benzyl Selenocyanate 100 mg 149.9 Organoselenium compound found in selenium-enriched garlic; potential PKA and PKC inhibitor. "Benzyl selenocyanate " Selenocyanic acid; benzyl ester; Selenocyanic acid; phenylmethyl ester (9CI) 4671-93-6 ≥98% 196.11 C8H7NSe C1=CC=C(C=C1)C[Se]C#N Ambient 4°C "El-Bayoumy K, Sinha R, Pinto JT, et al. Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. J Nutr. 2006 Mar;136(3 Suppl):864S-869S. PMID: 16484582. Fiala ES, Staretz ME, Pandya GA, et al. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis. 1998 Apr;19(4):597-604. PMID: 9600343. Foiles P, Fujiki H, Suganuma M, et al. Inhibition of pkc and pka by chemopreventive organoselenium compounds. Int J Oncol. 1995 Sep;7(3):685-90. PMID: 21552892. " B1654 Benzyl Selenocyanate 500 mg 637.6 Organoselenium compound found in selenium-enriched garlic; potential PKA and PKC inhibitor. "Benzyl selenocyanate " Selenocyanic acid; benzyl ester; Selenocyanic acid; phenylmethyl ester (9CI) 4671-93-6 ≥98% 196.11 C8H7NSe C1=CC=C(C=C1)C[Se]C#N Ambient 4°C "El-Bayoumy K, Sinha R, Pinto JT, et al. Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. J Nutr. 2006 Mar;136(3 Suppl):864S-869S. PMID: 16484582. Fiala ES, Staretz ME, Pandya GA, et al. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis. 1998 Apr;19(4):597-604. PMID: 9600343. Foiles P, Fujiki H, Suganuma M, et al. Inhibition of pkc and pka by chemopreventive organoselenium compounds. Int J Oncol. 1995 Sep;7(3):685-90. PMID: 21552892. " B1655 S-(N-Benzylthiocarbamoyl)-L-cysteine 500 mg 104.5 Cysteine conjugate of benzyl isothiocyanate (BITC); NMDA demethylase inhibitor. L-Cysteine, (phenylmethyl)carbamodithioate (ester) Benzyl isothiocyanate cysteine conjugate 35446-36-7 ≥98% 270.37 C11H14N2O2S2 C1=CC=C(C=C1)CNC(=S)SCC(C(=O)O)N Ambient -20°C Soluble in water. "Tang L, Li G, Song L, et al. The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anticancer Drugs. 2006 Mar;17(3):297-305. PMID: 16520658. Jiao D, Conaway CC, Wang MH, et al. Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates. Chem Res Toxicol. 1996 Sep;9(6):932-8. PMID: 8870979. Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92. PMID: 8641665. " Not dangerous goods. B1655 S-(N-Benzylthiocarbamoyl)-L-cysteine 1 g 181 Cysteine conjugate of benzyl isothiocyanate (BITC); NMDA demethylase inhibitor. L-Cysteine, (phenylmethyl)carbamodithioate (ester) Benzyl isothiocyanate cysteine conjugate 35446-36-7 ≥98% 270.37 C11H14N2O2S2 C1=CC=C(C=C1)CNC(=S)SCC(C(=O)O)N Ambient -20°C Soluble in water. "Tang L, Li G, Song L, et al. The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anticancer Drugs. 2006 Mar;17(3):297-305. PMID: 16520658. Jiao D, Conaway CC, Wang MH, et al. Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates. Chem Res Toxicol. 1996 Sep;9(6):932-8. PMID: 8870979. Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92. PMID: 8641665. " Not dangerous goods. B1655 S-(N-Benzylthiocarbamoyl)-L-cysteine 5 g 610.1 Cysteine conjugate of benzyl isothiocyanate (BITC); NMDA demethylase inhibitor. L-Cysteine, (phenylmethyl)carbamodithioate (ester) Benzyl isothiocyanate cysteine conjugate 35446-36-7 ≥98% 270.37 C11H14N2O2S2 C1=CC=C(C=C1)CNC(=S)SCC(C(=O)O)N Ambient -20°C Soluble in water. "Tang L, Li G, Song L, et al. The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anticancer Drugs. 2006 Mar;17(3):297-305. PMID: 16520658. Jiao D, Conaway CC, Wang MH, et al. Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates. Chem Res Toxicol. 1996 Sep;9(6):932-8. PMID: 8870979. Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92. PMID: 8641665. " Not dangerous goods. B1656 Benzyl Thiocyanate 50 g 71.8 Found in cruciferous vegetables. Benzyl rhodanide 3012-37-1 ≥98% 149.21 C8H7NS C1=CC=C(C=C1)CSC#N Ambient Ambient Insoluble in Water, Soluble in Alcohol and Ether "Musk SR, Stephenson P, Smith TK, et al. Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29. Nutr Cancer. 1995;24(3):289-98. PMID: 8610048. Sugie S, Okamoto K, Okumura A, et al. Inhibitory effects of benzyl thiocyanate and benzyl isothiocyanate on methylazoxymethanol acetate-induced intestinal carcinogenesis in rats. Carcinogenesis. 1994 Aug;15(8):1555-60. PMID: 8055633. " Xn, T+ "UN number: 3334 Class: 9 Packing group: III Proper shipping name: Aviation regulated liquid, n.o.s. (Benzyl thiocyanate) Marine pollutant: No Poison inhalation hazard: No" B1656 Benzyl Thiocyanate 100 g 97.2 Found in cruciferous vegetables. Benzyl rhodanide 3012-37-1 ≥98% 149.21 C8H7NS C1=CC=C(C=C1)CSC#N Ambient Ambient Insoluble in Water, Soluble in Alcohol and Ether "Musk SR, Stephenson P, Smith TK, et al. Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29. Nutr Cancer. 1995;24(3):289-98. PMID: 8610048. Sugie S, Okamoto K, Okumura A, et al. Inhibitory effects of benzyl thiocyanate and benzyl isothiocyanate on methylazoxymethanol acetate-induced intestinal carcinogenesis in rats. Carcinogenesis. 1994 Aug;15(8):1555-60. PMID: 8055633. " Xn, T+ "UN number: 3334 Class: 9 Packing group: III Proper shipping name: Aviation regulated liquid, n.o.s. (Benzyl thiocyanate) Marine pollutant: No Poison inhalation hazard: No" B1668 Berteroin 25 mg 115.5 Thio sulforaphane analog, ITC. 1-Isothiocyanato-5-(methylthio)-pentane "5-Methylthiopentyl isothiocyanate " 4430-42-6 ≥97% 175.43 C7H13NS2 CSCCCCCN=C=S Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Jung YJ, Jung JI, Cho HJ, et al. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin. Int J Mol Sci. 2014 Nov 11;15(11):20686-705. PMID: 25393510. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Kim SH, Singh SV. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells. Mol Cancer Ther. 2009 Jul;8(7):1946-54. PMID: 19584240. " Not dangerous goods. B1668 Berteroin 50 mg 199.5 Thio sulforaphane analog, ITC. 1-Isothiocyanato-5-(methylthio)-pentane "5-Methylthiopentyl isothiocyanate " 4430-42-6 ≥97% 175.43 C7H13NS2 CSCCCCCN=C=S Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Jung YJ, Jung JI, Cho HJ, et al. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin. Int J Mol Sci. 2014 Nov 11;15(11):20686-705. PMID: 25393510. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Kim SH, Singh SV. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells. Mol Cancer Ther. 2009 Jul;8(7):1946-54. PMID: 19584240. " Not dangerous goods. B1668 Berteroin 100 mg 346.5 Thio sulforaphane analog, ITC. 1-Isothiocyanato-5-(methylthio)-pentane "5-Methylthiopentyl isothiocyanate " 4430-42-6 ≥97% 175.43 C7H13NS2 CSCCCCCN=C=S Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Jung YJ, Jung JI, Cho HJ, et al. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin. Int J Mol Sci. 2014 Nov 11;15(11):20686-705. PMID: 25393510. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Kim SH, Singh SV. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells. Mol Cancer Ther. 2009 Jul;8(7):1946-54. PMID: 19584240. " Not dangerous goods. B1668 Berteroin 500 mg 1155 Thio sulforaphane analog, ITC. 1-Isothiocyanato-5-(methylthio)-pentane "5-Methylthiopentyl isothiocyanate " 4430-42-6 ≥97% 175.43 C7H13NS2 CSCCCCCN=C=S Ambient -20°C Soluble in DMSO, ethanol, or chloroform. "Jung YJ, Jung JI, Cho HJ, et al. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin. Int J Mol Sci. 2014 Nov 11;15(11):20686-705. PMID: 25393510. Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144. Kim SH, Singh SV. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells. Mol Cancer Ther. 2009 Jul;8(7):1946-54. PMID: 19584240. " Not dangerous goods. B3373 Bis(aziridinyl)methylamino Phosphine Sulfide 500 mg 99.9 Insect sterilizer; mutagenic. Bis(aziridinyl)methylamino phosphine sulfide Bisazir 13687-09-7 ≥98% 177.21 C5H12N3PS CNP(=S)(N1CC1)N2CC2 Dry Ice -20°C Soluble in DMSO. "Ciereszko A, Wolfe TD, Dabrowski K. Analysis of DNA damage in sea lamprey (Petromyzon marinus) spermatozoa by UV, hydrogen peroxide, and the toxicant bisazir. Theriogenology. Aquat Toxicol. 2005 Jun 15;73(2):128-38. PMID: 15885821. Ciereszko A, Babiak I, Dabrowski K. Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa. Theriogenology. 2004 Apr 15;61(6):1039-50. PMID: 15036993. Srivastava VK, Kumar K. Effect of the chemosterilant bisazir on the testes of the spotted bollworm Earias fabia stoll. Toxicology. 1984 Jun;31(3-4):335-42. PMID: 6740707. " Not dangerous goods. B3373 Bis(aziridinyl)methylamino Phosphine Sulfide 1 g 168.6 Insect sterilizer; mutagenic. Bis(aziridinyl)methylamino phosphine sulfide Bisazir 13687-09-7 ≥98% 177.21 C5H12N3PS CNP(=S)(N1CC1)N2CC2 Dry Ice -20°C Soluble in DMSO. "Ciereszko A, Wolfe TD, Dabrowski K. Analysis of DNA damage in sea lamprey (Petromyzon marinus) spermatozoa by UV, hydrogen peroxide, and the toxicant bisazir. Theriogenology. Aquat Toxicol. 2005 Jun 15;73(2):128-38. PMID: 15885821. Ciereszko A, Babiak I, Dabrowski K. Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa. Theriogenology. 2004 Apr 15;61(6):1039-50. PMID: 15036993. Srivastava VK, Kumar K. Effect of the chemosterilant bisazir on the testes of the spotted bollworm Earias fabia stoll. Toxicology. 1984 Jun;31(3-4):335-42. PMID: 6740707. " Not dangerous goods. B3373 Bis(aziridinyl)methylamino Phosphine Sulfide 5 g 670.2 Insect sterilizer; mutagenic. Bis(aziridinyl)methylamino phosphine sulfide Bisazir 13687-09-7 ≥98% 177.21 C5H12N3PS CNP(=S)(N1CC1)N2CC2 Dry Ice -20°C Soluble in DMSO. "Ciereszko A, Wolfe TD, Dabrowski K. Analysis of DNA damage in sea lamprey (Petromyzon marinus) spermatozoa by UV, hydrogen peroxide, and the toxicant bisazir. Theriogenology. Aquat Toxicol. 2005 Jun 15;73(2):128-38. PMID: 15885821. Ciereszko A, Babiak I, Dabrowski K. Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa. Theriogenology. 2004 Apr 15;61(6):1039-50. PMID: 15036993. Srivastava VK, Kumar K. Effect of the chemosterilant bisazir on the testes of the spotted bollworm Earias fabia stoll. Toxicology. 1984 Jun;31(3-4):335-42. PMID: 6740707. " Not dangerous goods. B3272 Bis(3,5-dibromosalicyl) Fumarate 100 mg 27.6 Aspirin analog; hemoglobin chain cross-linker. 2-Butenedioic acid (E)-, bis(2,4-dibromo-6-carboxyphenyl) ester "3,5-Dibromosalicyl-bis-fumarate " 71337-53-6 ≥91% 671.87 C18H8O8Br4 C1=C(C=C(C(=C1Br)OC(=O)C=CC(=O)OC2=C(C=C(C=C2C(=O)O)Br)Br)C(=O)O)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3272 Bis(3,5-dibromosalicyl) Fumarate 500 mg 96.2 Aspirin analog; hemoglobin chain cross-linker. 2-Butenedioic acid (E)-, bis(2,4-dibromo-6-carboxyphenyl) ester "3,5-Dibromosalicyl-bis-fumarate " 71337-53-6 ≥91% 671.87 C18H8O8Br4 C1=C(C=C(C(=C1Br)OC(=O)C=CC(=O)OC2=C(C=C(C=C2C(=O)O)Br)Br)C(=O)O)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3272 Bis(3,5-dibromosalicyl) Fumarate 1 g 137.1 Aspirin analog; hemoglobin chain cross-linker. 2-Butenedioic acid (E)-, bis(2,4-dibromo-6-carboxyphenyl) ester "3,5-Dibromosalicyl-bis-fumarate " 71337-53-6 ≥91% 671.87 C18H8O8Br4 C1=C(C=C(C(=C1Br)OC(=O)C=CC(=O)OC2=C(C=C(C=C2C(=O)O)Br)Br)C(=O)O)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3272 Bis(3,5-dibromosalicyl) Fumarate 5 g 274.7 Aspirin analog; hemoglobin chain cross-linker. 2-Butenedioic acid (E)-, bis(2,4-dibromo-6-carboxyphenyl) ester "3,5-Dibromosalicyl-bis-fumarate " 71337-53-6 ≥91% 671.87 C18H8O8Br4 C1=C(C=C(C(=C1Br)OC(=O)C=CC(=O)OC2=C(C=C(C=C2C(=O)O)Br)Br)C(=O)O)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3275 Bis(3,5-dibromosalicyl) Succinate 100 mg 27.6 Aspirin analog; hemoglobin chain cross-linker. 3,5-dibromo-2-[4-(2,4-dibromo-6-carboxyphenoxy)-4-oxobutanoyl]oxybenzoic acid 71337-52-5 ≥95% 673.89 C18H10O8Br4 c1c(cc(c(c1C(=O)O)OC(=O)CCC(=O)Oc2c(cc(cc2Br)Br)C(=O)O)Br)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3275 Bis(3,5-dibromosalicyl) Succinate 500 mg 96.2 Aspirin analog; hemoglobin chain cross-linker. 3,5-dibromo-2-[4-(2,4-dibromo-6-carboxyphenoxy)-4-oxobutanoyl]oxybenzoic acid 71337-52-5 ≥95% 673.89 C18H10O8Br4 c1c(cc(c(c1C(=O)O)OC(=O)CCC(=O)Oc2c(cc(cc2Br)Br)C(=O)O)Br)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3275 Bis(3,5-dibromosalicyl) Succinate 1 g 137.1 Aspirin analog; hemoglobin chain cross-linker. 3,5-dibromo-2-[4-(2,4-dibromo-6-carboxyphenoxy)-4-oxobutanoyl]oxybenzoic acid 71337-52-5 ≥95% 673.89 C18H10O8Br4 c1c(cc(c(c1C(=O)O)OC(=O)CCC(=O)Oc2c(cc(cc2Br)Br)C(=O)O)Br)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3275 Bis(3,5-dibromosalicyl) Succinate 5 g 274.7 Aspirin analog; hemoglobin chain cross-linker. 3,5-dibromo-2-[4-(2,4-dibromo-6-carboxyphenoxy)-4-oxobutanoyl]oxybenzoic acid 71337-52-5 ≥95% 673.89 C18H10O8Br4 c1c(cc(c(c1C(=O)O)OC(=O)CCC(=O)Oc2c(cc(cc2Br)Br)C(=O)O)Br)Br Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3280 Bis(salicyl) Fumarate 100 mg 27.6 Aspirin analog; hemoglobin chain cross-linker. ≥98% 356.29 C18H12O8 Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3280 Bis(salicyl) Fumarate 500 mg 96.2 Aspirin analog; hemoglobin chain cross-linker. ≥98% 356.29 C18H12O8 Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3280 Bis(salicyl) Fumarate 1 g 137.1 Aspirin analog; hemoglobin chain cross-linker. ≥98% 356.29 C18H12O8 Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B3280 Bis(salicyl) Fumarate 5 g 274.7 Aspirin analog; hemoglobin chain cross-linker. ≥98% 356.29 C18H12O8 Ambient -20°C "Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376. Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420. Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320. " Not dangerous goods. B6801 Brassinin 50 mg 144.1 Phytoalexin, indole found in cruciferous vegetables; indoleamine-2,3-dioxygenase inhibitor. methyl (1H-indol-3-ylmethylamino)methanedithioate methyl N-(1H-indol-3-ylmethyl)-carbamodithioate 105748-59-2 ≥98% 236.36 C11H12N2S2 CSC(=S)NCC1=CNC2=CC=CC=C21 Ambient -20°C Soluble in DMSO. "Kim SM, Park JH, Kim KD, et al. Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades. Phytother Res. 2014 Mar;28(3):423-31. PMID: 23686889. Banerjee T, Duhadaway JB, Gaspari P, et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7. PMID: 18026137. Mehta RG, Liu J, Constantinou A, et al. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis. 1995 Feb;16(2):399-404. PMID: 7859373. " Not dangerous goods. B6801 Brassinin 100 mg 230.7 Phytoalexin, indole found in cruciferous vegetables; indoleamine-2,3-dioxygenase inhibitor. methyl (1H-indol-3-ylmethylamino)methanedithioate methyl N-(1H-indol-3-ylmethyl)-carbamodithioate 105748-59-2 ≥98% 236.36 C11H12N2S2 CSC(=S)NCC1=CNC2=CC=CC=C21 Ambient -20°C Soluble in DMSO. "Kim SM, Park JH, Kim KD, et al. Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades. Phytother Res. 2014 Mar;28(3):423-31. PMID: 23686889. Banerjee T, Duhadaway JB, Gaspari P, et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7. PMID: 18026137. Mehta RG, Liu J, Constantinou A, et al. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis. 1995 Feb;16(2):399-404. PMID: 7859373. " Not dangerous goods. B6801 Brassinin 250 mg 480.3 Phytoalexin, indole found in cruciferous vegetables; indoleamine-2,3-dioxygenase inhibitor. methyl (1H-indol-3-ylmethylamino)methanedithioate methyl N-(1H-indol-3-ylmethyl)-carbamodithioate 105748-59-2 ≥98% 236.36 C11H12N2S2 CSC(=S)NCC1=CNC2=CC=CC=C21 Ambient -20°C Soluble in DMSO. "Kim SM, Park JH, Kim KD, et al. Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades. Phytother Res. 2014 Mar;28(3):423-31. PMID: 23686889. Banerjee T, Duhadaway JB, Gaspari P, et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7. PMID: 18026137. Mehta RG, Liu J, Constantinou A, et al. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis. 1995 Feb;16(2):399-404. PMID: 7859373. " Not dangerous goods. B6856 5-Bromo-2′-Deoxyuridine 250 mg 40.3 Nucleoside (thymidine) analog. 5-Bromo-2'-deoxyuridine Broxuridine; 5-bromouracil deoxyriboside; BUdR; Broxine; Neomark; Radibud 59-14-3 ≥98% 307.11 C9H11BrN2O5 C1C(C(OC1N2C=C(C(=O)NC2=O)Br)CO)O Ambient -20°C Soluble in dimethyl- acetamide, 1N NaOH, or dimethylsulfoxide. Slightly soluble in water. "Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Jeong CH, Kim SM, Lim JY, et al. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed Res Int. 2014;2014:129145. PMID: 24672780. Russo A, Gianni L, Kinsella TJ, et al. Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors. Cancer Res. 1984 Apr;44(4):1702-5. PMID: 6704976. " Xn, Xi Not dangerous goods. B6856 5-Bromo-2′-Deoxyuridine 500 mg 64.4 Nucleoside (thymidine) analog. 5-Bromo-2'-deoxyuridine Broxuridine; 5-bromouracil deoxyriboside; BUdR; Broxine; Neomark; Radibud 59-14-3 ≥98% 307.11 C9H11BrN2O5 C1C(C(OC1N2C=C(C(=O)NC2=O)Br)CO)O Ambient -20°C Soluble in dimethyl- acetamide, 1N NaOH, or dimethylsulfoxide. Slightly soluble in water. "Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Jeong CH, Kim SM, Lim JY, et al. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed Res Int. 2014;2014:129145. PMID: 24672780. Russo A, Gianni L, Kinsella TJ, et al. Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors. Cancer Res. 1984 Apr;44(4):1702-5. PMID: 6704976. " Xn, Xi Not dangerous goods. B6856 5-Bromo-2′-Deoxyuridine 1 g 108.9 Nucleoside (thymidine) analog. 5-Bromo-2'-deoxyuridine Broxuridine; 5-bromouracil deoxyriboside; BUdR; Broxine; Neomark; Radibud 59-14-3 ≥98% 307.11 C9H11BrN2O5 C1C(C(OC1N2C=C(C(=O)NC2=O)Br)CO)O Ambient -20°C Soluble in dimethyl- acetamide, 1N NaOH, or dimethylsulfoxide. Slightly soluble in water. "Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Jeong CH, Kim SM, Lim JY, et al. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed Res Int. 2014;2014:129145. PMID: 24672780. Russo A, Gianni L, Kinsella TJ, et al. Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors. Cancer Res. 1984 Apr;44(4):1702-5. PMID: 6704976. " Xn, Xi Not dangerous goods. B6856 5-Bromo-2′-Deoxyuridine 5 g 353.3 Nucleoside (thymidine) analog. 5-Bromo-2'-deoxyuridine Broxuridine; 5-bromouracil deoxyriboside; BUdR; Broxine; Neomark; Radibud 59-14-3 ≥98% 307.11 C9H11BrN2O5 C1C(C(OC1N2C=C(C(=O)NC2=O)Br)CO)O Ambient -20°C Soluble in dimethyl- acetamide, 1N NaOH, or dimethylsulfoxide. Slightly soluble in water. "Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Jeong CH, Kim SM, Lim JY, et al. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed Res Int. 2014;2014:129145. PMID: 24672780. Russo A, Gianni L, Kinsella TJ, et al. Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors. Cancer Res. 1984 Apr;44(4):1702-5. PMID: 6704976. " Xn, Xi Not dangerous goods. B7973 Busulfan 10 g 30.2 Alkyl sulfonate; DNA alkylator. 1,4-Butanediol dimethanesulfonate esters Busulphan 55-98-1 ≥98% 246.3 C6H14O6S2 CS(=O)(=O)OCCCCOS(=O)(=O)C Ambient Ambient Soluble in acetone (22 mg/mL), ethanol, or DMSO. Insoluble in water. "Galaup A, Paci A. Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):333-47. PMID: 23157726. Probin V, Wang Y, Zhou D. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65. PMID: 17512465. Frame D. Chronic myeloid leukemia: standard treatment options. Am J Health Syst Pharm. 2006 Dec 1;63(23 Suppl 8):S10-4; quiz S21-2. PMID: 17106015. Iwamoto T, Hiraku Y, Oikawa S, et al. DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8. PMID: 15132775. " Carc., T, Repr. T+, Xi, Mut. "UN number: 2811 Class: 6.1 Packing group: III Proper shipping name: Toxic solids, organic, n.o.s. (Busulfan) Marine pollutant: No Poison inhalation hazard: No" B7973 Busulfan 25 g 60.5 Alkyl sulfonate; DNA alkylator. 1,4-Butanediol dimethanesulfonate esters Busulphan 55-98-1 ≥98% 246.3 C6H14O6S2 CS(=O)(=O)OCCCCOS(=O)(=O)C Ambient Ambient Soluble in acetone (22 mg/mL), ethanol, or DMSO. Insoluble in water. "Galaup A, Paci A. Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):333-47. PMID: 23157726. Probin V, Wang Y, Zhou D. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65. PMID: 17512465. Frame D. Chronic myeloid leukemia: standard treatment options. Am J Health Syst Pharm. 2006 Dec 1;63(23 Suppl 8):S10-4; quiz S21-2. PMID: 17106015. Iwamoto T, Hiraku Y, Oikawa S, et al. DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8. PMID: 15132775. " Carc., T, Repr. T+, Xi, Mut. "UN number: 2811 Class: 6.1 Packing group: III Proper shipping name: Toxic solids, organic, n.o.s. (Busulfan) Marine pollutant: No Poison inhalation hazard: No" B7977 Butylated Hydroxytoluene 100 g 34.8 Antioxidative food and cosmetics additive. 2,6-Bis-(1,1-dimethylethyl)-4-methylphenol BHT; Antracine 8; Ionol CP; Sustane; Dalpac; Impruvol; Vianol 128-37-0 ≥98% 220.35 C15H24O CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C Ambient Ambient Insoluble in water. Soluble in ethanol, acetone, or DMSO. "Lee JH, Jung MY. Direct spectroscopic observation of singlet oxygen quenching and kinetic studies of physical and chemical singlet oxygen quenching rate constants of synthetic antioxidants (BHA, BHT, and TBHQ) in methanol. J Food Sci. 2010 Aug 1;75(6):C506-13. PMID: 20722904. Crews F, Nixon K, Kim D, et al. BHT blocks NF-kappaB activation and ethanol-induced brain damage. Alcohol Clin Exp Res. 2006 Nov;30(11):1938-49. PMID: 17067360. " Xn, Xi Not dangerous goods. B7977 Butylated Hydroxytoluene 500 g 84.3 Antioxidative food and cosmetics additive. 2,6-Bis-(1,1-dimethylethyl)-4-methylphenol BHT; Antracine 8; Ionol CP; Sustane; Dalpac; Impruvol; Vianol 128-37-0 ≥98% 220.35 C15H24O CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C Ambient Ambient Insoluble in water. Soluble in ethanol, acetone, or DMSO. "Lee JH, Jung MY. Direct spectroscopic observation of singlet oxygen quenching and kinetic studies of physical and chemical singlet oxygen quenching rate constants of synthetic antioxidants (BHA, BHT, and TBHQ) in methanol. J Food Sci. 2010 Aug 1;75(6):C506-13. PMID: 20722904. Crews F, Nixon K, Kim D, et al. BHT blocks NF-kappaB activation and ethanol-induced brain damage. Alcohol Clin Exp Res. 2006 Nov;30(11):1938-49. PMID: 17067360. " Xn, Xi Not dangerous goods. B8070 2-tert-Butyl-4-Hydroxyanisole 100 mg 100.6 BHA derivative, antioxidative food and cosmetics additive. 2-(1,1-Di-methylethyl)4-methoxyphenol 2-BHA 88-32-4 ≥99% 180.25 C11H16O2 CC(C)(C)C1=C(C=CC(=C1)O)OC Ambient Ambient Insoluble in water. Soluble in ethanol, acetone, or DMSO. "Hwang GH, Jeon YJ, Han HJ, et al. Protective effect of butylated hydroxylanisole against hydrogen peroxide-induced apoptosis in primary cultured mouse hepatocytes. J Vet Sci. 2014 Oct 8. [Epub ahead of print]. PMID: 25293491. Nishiya H, Haga T, Nozue N, et al. Effects of 2(3)-tert-butyl-4-hydroxyanisole pretreatment on cefpiramide binding to mouse glutathione S-transferases. Pharmacology. 1989;39(4):213-23. PMID: 2608720. " Not dangerous goods. B8070 2-tert-Butyl-4-Hydroxyanisole 500 mg 289.3 BHA derivative, antioxidative food and cosmetics additive. 2-(1,1-Di-methylethyl)4-methoxyphenol 2-BHA 88-32-4 ≥99% 180.25 C11H16O2 CC(C)(C)C1=C(C=CC(=C1)O)OC Ambient Ambient Insoluble in water. Soluble in ethanol, acetone, or DMSO. "Hwang GH, Jeon YJ, Han HJ, et al. Protective effect of butylated hydroxylanisole against hydrogen peroxide-induced apoptosis in primary cultured mouse hepatocytes. J Vet Sci. 2014 Oct 8. [Epub ahead of print]. PMID: 25293491. Nishiya H, Haga T, Nozue N, et al. Effects of 2(3)-tert-butyl-4-hydroxyanisole pretreatment on cefpiramide binding to mouse glutathione S-transferases. Pharmacology. 1989;39(4):213-23. PMID: 2608720. " Not dangerous goods. B8070 2-tert-Butyl-4-Hydroxyanisole 1 g 452 BHA derivative, antioxidative food and cosmetics additive. 2-(1,1-Di-methylethyl)4-methoxyphenol 2-BHA 88-32-4 ≥99% 180.25 C11H16O2 CC(C)(C)C1=C(C=CC(=C1)O)OC Ambient Ambient Insoluble in water. Soluble in ethanol, acetone, or DMSO. "Hwang GH, Jeon YJ, Han HJ, et al. Protective effect of butylated hydroxylanisole against hydrogen peroxide-induced apoptosis in primary cultured mouse hepatocytes. J Vet Sci. 2014 Oct 8. [Epub ahead of print]. PMID: 25293491. Nishiya H, Haga T, Nozue N, et al. Effects of 2(3)-tert-butyl-4-hydroxyanisole pretreatment on cefpiramide binding to mouse glutathione S-transferases. Pharmacology. 1989;39(4):213-23. PMID: 2608720. " Not dangerous goods. B8071 3-tert-Butyl-4-Hydroxyanisole 10 g 197 BHA derivative, antioxidative food and cosmetics additive. 3-(1,1-Di-methylethyl)4-methoxyphenol 3-BHA 121-00-6 ≥99% 180.25 C11H16O2 CC(C)(C)C1=C(C=CC(=C1)OC)O Ambient Ambient Insoluble in water. Soluble in ethanol, acetone, or DMSO. "Hwang GH, Jeon YJ, Han HJ, et al. Protective effect of butylated hydroxylanisole against hydrogen peroxide-induced apoptosis in primary cultured mouse hepatocytes. J Vet Sci. 2014 Oct 8. [Epub ahead of print]. PMID: 25293491. Okubo T, Yokoyama Y, Kano K, et al. Molecular mechanism of cell death induced by the antioxidant tert-butylhydroxyanisole in human monocytic leukemia U937 cells. Biol Pharm Bull. 2004 Mar;27(3):295-302. PMID: 14993791. Prochaska HJ, Fernandes CL. Elevation of serum phase II enzymes by anticarcinogenic enzyme inducers: markers for a chemoprotected state? Carcinogenesis. 1993 Dec;14(12):2441-5. PMID: 8269610. Matsuoka A, Matsui M, Miyata N, et al. Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites in short-term tests in vitro. Mutat Res. 1990 Jun;241(2):125-32. PMID: 2345551. " Xi Not dangerous goods. B8071 3-tert-Butyl-4-Hydroxyanisole 50 g 638.2 BHA derivative, antioxidative food and cosmetics additive. 3-(1,1-Di-methylethyl)4-methoxyphenol 3-BHA 121-00-6 ≥99% 180.25 C11H16O2 CC(C)(C)C1=C(C=CC(=C1)OC)O Ambient Ambient Insoluble in water. Soluble in ethanol, acetone, or DMSO. "Hwang GH, Jeon YJ, Han HJ, et al. Protective effect of butylated hydroxylanisole against hydrogen peroxide-induced apoptosis in primary cultured mouse hepatocytes. J Vet Sci. 2014 Oct 8. [Epub ahead of print]. PMID: 25293491. Okubo T, Yokoyama Y, Kano K, et al. Molecular mechanism of cell death induced by the antioxidant tert-butylhydroxyanisole in human monocytic leukemia U937 cells. Biol Pharm Bull. 2004 Mar;27(3):295-302. PMID: 14993791. Prochaska HJ, Fernandes CL. Elevation of serum phase II enzymes by anticarcinogenic enzyme inducers: markers for a chemoprotected state? Carcinogenesis. 1993 Dec;14(12):2441-5. PMID: 8269610. Matsuoka A, Matsui M, Miyata N, et al. Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites in short-term tests in vitro. Mutat Res. 1990 Jun;241(2):125-32. PMID: 2345551. " Xi Not dangerous goods. B8072 3-tert-Butyl-5-Methoxycatechol 10 mg 112.6 BHA derivative, cellular differentiation inducer. 3-tert-butyl-5-methoxybenzene-1,2-diol 3-(1,1-Dimethylethyl)-5-methoxy-1,2-benzenediol; 3-tert-Butyl-4,5-dihydroxyanisole 80284-15-7 ≥98% 196.25 C11H16O3 CC(C)(C)C1=CC(=CC(=C1O)O)OC Ambient -20°C Partly miscible in Water "Tsuchiya T, Ishida A, Miyata N, et al. Effects of 3-tert-Butyl-4-hydroxyanisole and its hydroquinone and quinone metabolites on rat and human embryonic cells in culture. Toxicol In Vitro. 1988;2(4):291-6. PMID: 20837439. Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. " Not dangerous goods. B8072 3-tert-Butyl-5-Methoxycatechol 50 mg 341.8 BHA derivative, cellular differentiation inducer. 3-tert-butyl-5-methoxybenzene-1,2-diol 3-(1,1-Dimethylethyl)-5-methoxy-1,2-benzenediol; 3-tert-Butyl-4,5-dihydroxyanisole 80284-15-7 ≥98% 196.25 C11H16O3 CC(C)(C)C1=CC(=CC(=C1O)O)OC Ambient -20°C Partly miscible in Water "Tsuchiya T, Ishida A, Miyata N, et al. Effects of 3-tert-Butyl-4-hydroxyanisole and its hydroquinone and quinone metabolites on rat and human embryonic cells in culture. Toxicol In Vitro. 1988;2(4):291-6. PMID: 20837439. Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. " Not dangerous goods. B8072 3-tert-Butyl-5-Methoxycatechol 100 mg 602.5 BHA derivative, cellular differentiation inducer. 3-tert-butyl-5-methoxybenzene-1,2-diol 3-(1,1-Dimethylethyl)-5-methoxy-1,2-benzenediol; 3-tert-Butyl-4,5-dihydroxyanisole 80284-15-7 ≥98% 196.25 C11H16O3 CC(C)(C)C1=CC(=CC(=C1O)O)OC Ambient -20°C Partly miscible in Water "Tsuchiya T, Ishida A, Miyata N, et al. Effects of 3-tert-Butyl-4-hydroxyanisole and its hydroquinone and quinone metabolites on rat and human embryonic cells in culture. Toxicol In Vitro. 1988;2(4):291-6. PMID: 20837439. Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. " Not dangerous goods. B8073 4-tert-Butyl-5-Methoxycatechol 10 mg 129 BHA derivative. 91352-66-8 ≥98% 196.25 C11H16O3 CC(C)(C)C1=CC(=C(C=C1OC)O)O Ambient -20°C Partly miscible in Water Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Xi Not dangerous goods. B8073 4-tert-Butyl-5-Methoxycatechol 50 mg 401.7 BHA derivative. 91352-66-8 ≥98% 196.25 C11H16O3 CC(C)(C)C1=CC(=C(C=C1OC)O)O Ambient -20°C Partly miscible in Water Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Xi Not dangerous goods. B8073 4-tert-Butyl-5-Methoxycatechol 100 mg 702.6 BHA derivative. 91352-66-8 ≥98% 196.25 C11H16O3 CC(C)(C)C1=CC(=C(C=C1OC)O)O Ambient -20°C Partly miscible in Water Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Xi Not dangerous goods. B8074 3-tert-Butyl-5-Methoxy-1,2-quinone 50 mg 181 BHA derivative. 2940-63-8 ≥98% 194.25 C11H14O3 CC(C)(C)C1=CC(=CC(=O)C1=O)OC Ambient -20°C Partly miscible in Water Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Not dangerous goods. B8074 3-tert-Butyl-5-Methoxy-1,2-quinone 100 mg 321.3 BHA derivative. 2940-63-8 ≥98% 194.25 C11H14O3 CC(C)(C)C1=CC(=CC(=O)C1=O)OC Ambient -20°C Partly miscible in Water Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Not dangerous goods. B8074 3-tert-Butyl-5-Methoxy-1,2-quinone 500 mg 1035.7 BHA derivative. 2940-63-8 ≥98% 194.25 C11H14O3 CC(C)(C)C1=CC(=CC(=O)C1=O)OC Ambient -20°C Partly miscible in Water Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Not dangerous goods. B8075 4-tert-Butyl-5-Methoxy-1,2-quinone 50 mg 261.2 BHA derivative. 36122-03-9 ≥98% 194.25 C11H14O3 CC(C)(C)C1=CC(=O)C(=O)C=C1OC Ambient -20°C Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Not dangerous goods. B8075 4-tert-Butyl-5-Methoxy-1,2-quinone 100 mg 462.1 BHA derivative. 36122-03-9 ≥98% 194.25 C11H14O3 CC(C)(C)C1=CC(=O)C(=O)C=C1OC Ambient -20°C Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Not dangerous goods. B8075 4-tert-Butyl-5-Methoxy-1,2-quinone 500 mg 1484.9 BHA derivative. 36122-03-9 ≥98% 194.25 C11H14O3 CC(C)(C)C1=CC(=O)C(=O)C=C1OC Ambient -20°C Lam LK, Garg PK, Swanson SM, et al. Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole. J Pharm Sci. 1988 May;77(5):393-5. PMID: 3411459. Not dangerous goods. B8176 2-n-Butylthiophene 5 g 100.6 Sulfur analog of furan found in cooked meat products. 1455-20-5 ≥98% 140.25 C8H12S CCCCC1=CC=CS1 Ambient Ambient Soluble in acetone, DMSO or ethanol. Lam LK, Zheng BL. Inhibitory effects of 2-n-heptylfuran and 2-n-butylthiophene on benzo[a]pyrene-induced lung and forestomach tumorigenesis in A/J mice. Nutr Cancer. 1992;17(1):19-26. PMID: 1574441. "UN number: 1993 Class: 3 (F1) Packing Group: III Proper shipping name: Flammable liquid, n.o.s. (2-n-Butylthiophene) " B8176 2-n-Butylthiophene 10 g 184.8 Sulfur analog of furan found in cooked meat products. 1455-20-5 ≥98% 140.25 C8H12S CCCCC1=CC=CS1 Ambient Ambient Soluble in acetone, DMSO or ethanol. Lam LK, Zheng BL. Inhibitory effects of 2-n-heptylfuran and 2-n-butylthiophene on benzo[a]pyrene-induced lung and forestomach tumorigenesis in A/J mice. Nutr Cancer. 1992;17(1):19-26. PMID: 1574441. "UN number: 1993 Class: 3 (F1) Packing Group: III Proper shipping name: Flammable liquid, n.o.s. (2-n-Butylthiophene) " C0020 Cafestol 50 mg 220.1 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol Cafesterol 469-83-0 ≥98% 316.44 C20H28O3 CC12CCC3=C(C1CCC45C2CCC(C4)C(C5)(CO)O)C=CO3 Ambient -20°C Insoluble in water. Soluble in DMSO or ethanol to 10 mM, DMF to 12 mg/mL, ethyl acetate or acetone. "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0020 Cafestol 100 mg 341.8 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol Cafesterol 469-83-0 ≥98% 316.44 C20H28O3 CC12CCC3=C(C1CCC45C2CCC(C4)C(C5)(CO)O)C=CO3 Ambient -20°C Insoluble in water. Soluble in DMSO or ethanol to 10 mM, DMF to 12 mg/mL, ethyl acetate or acetone. "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0020 Cafestol 500 mg 1204.1 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol Cafesterol 469-83-0 ≥98% 316.44 C20H28O3 CC12CCC3=C(C1CCC45C2CCC(C4)C(C5)(CO)O)C=CO3 Ambient -20°C Insoluble in water. Soluble in DMSO or ethanol to 10 mM, DMF to 12 mg/mL, ethyl acetate or acetone. "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0021 Cafestol Acetate 50 mg 226.9 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol acetate Cafesterol acetate 81760-48-7 ≥98% 358.48 C22H30O4 CC(=O)OCC1(CC23CCC4C5=C(CCC4(C2CCC1C3)C)OC=C5)O Ambient -20°C Insoluble in water. Soluble in DMSO, ethyl acetate, acetone. "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0021 Cafestol Acetate 100 mg 361.3 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol acetate Cafesterol acetate 81760-48-7 ≥98% 358.48 C22H30O4 CC(=O)OCC1(CC23CCC4C5=C(CCC4(C2CCC1C3)C)OC=C5)O Ambient -20°C Insoluble in water. Soluble in DMSO, ethyl acetate, acetone. "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0021 Cafestol Acetate 500 mg 1244.9 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol acetate Cafesterol acetate 81760-48-7 ≥98% 358.48 C22H30O4 CC(=O)OCC1(CC23CCC4C5=C(CCC4(C2CCC1C3)C)OC=C5)O Ambient -20°C Insoluble in water. Soluble in DMSO, ethyl acetate, acetone. "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0022 Cafestol Palmitate 50 mg 231.4 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol palmitate Cafesterol palmitate 81760-46-5 ≥98% 554.43 C36H58O4 CCCCCCCCCCCCCCCC(=O)OCC1(CC23CCC4C5=C(CCC4(C2CCC1C3)C)OC=C5)O Ambient -20°C "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0022 Cafestol Palmitate 100 mg 361.3 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol palmitate Cafesterol palmitate 81760-46-5 ≥98% 554.43 C36H58O4 CCCCCCCCCCCCCCCC(=O)OCC1(CC23CCC4C5=C(CCC4(C2CCC1C3)C)OC=C5)O Ambient -20°C "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0022 Cafestol Palmitate 500 mg 1244.9 Diterpene found in brewed, unfiltered coffee; FXR and PXR agonist, ERK2 and MEK1 inhibitor. [3b,S-(3bα,β,7β,8β,10aα,10bβ)]-3b,4,5,6,7,8,9,10- 10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl- ,8-methano-H-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol palmitate Cafesterol palmitate 81760-46-5 ≥98% 554.43 C36H58O4 CCCCCCCCCCCCCCCC(=O)OCC1(CC23CCC4C5=C(CCC4(C2CCC1C3)C)OC=C5)O Ambient -20°C "Wang S, Yoon YC, Sung MJ, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. PMID: 22525673. Choi MJ, Park EJ, Oh JH, et al. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem Biol Interact. 2011 Apr 25;190(2-3):102-8. PMID: 21334318. Trinh K, Andrews L, Krause J, et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. J Neurosci. 2010 Apr 21;30(16):5525-32. PMID: 20410106. Shen T, Lee J, Lee E, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. PMID: 20045950. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul;21(7):1603-16. PMID: 17456796. Cavin C, Holzhäuser D, Constable A, et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998 Aug;19(8):1369-75. PMID: 9744531. " Not dangerous goods. C0121 Caffeic Acid 5 g 41.4 Hydroxycinnamic acid found in coffee, argan oil, Eucaplyptus, Salvinia, and Phellinus; α-amylase and α-glucosidase inhibitor. 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 3,4-Dihydroxycinnamic acid 331-39-5 ≥98% 180.16 C9H8O4 C1=CC(=C(C=C1C=CC(=O)O)O)O Ambient Ambient Sparingly soluble in water. Soluble in DMSO. "Oboh G, Agunloye OM, Adefegha SA, et al. Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J Basic Clin Physiol Pharmacol. 2014 May 12. [Epub ahead of print]. PMID: 24825096. Liu M, Song S, Li H, et al. The protective effect of caffeic acid against inflammation injury of primary bovine mammary epithelial cells induced by lipopolysaccharide. J Dairy Sci. 2014 May;97(5):2856-65. PMID: 24612802. Luís Â, Silva F, Sousa S, et al. Antistaphylococcal and biofilm inhibitory activities of gallic, caffeic, and chlorogenic acids. Biofouling. 2014 Jan;30(1):69-79. PMID: 24228999. Tsai CM, Yen GC, Sun FM, et al. Assessment of the anti-invasion potential and mechanism of select cinnamic acid derivatives on human lung adenocarcinoma cells. Mol Pharm. 2013 May 6;10(5):1890-900. PMID: 23560439. Jaganathan SK. Growth inhibition by caffeic acid, one of the phenolic constituents of honey, in HCT 15 colon cancer cells. ScientificWorldJournal. 2012;2012:372345. PMID: 22649289. Pluemsamran T, Onkoksoong T, Panich U. Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells. Photochem Photobiol. 2012 Jul-Aug;88(4):961-8. PMID: 22360712. " Carc., Xi Not dangerous goods. C0121 Caffeic Acid 25 g 116.5 Hydroxycinnamic acid found in coffee, argan oil, Eucaplyptus, Salvinia, and Phellinus; α-amylase and α-glucosidase inhibitor. 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 3,4-Dihydroxycinnamic acid 331-39-5 ≥98% 180.16 C9H8O4 C1=CC(=C(C=C1C=CC(=O)O)O)O Ambient Ambient Sparingly soluble in water. Soluble in DMSO. "Oboh G, Agunloye OM, Adefegha SA, et al. Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J Basic Clin Physiol Pharmacol. 2014 May 12. [Epub ahead of print]. PMID: 24825096. Liu M, Song S, Li H, et al. The protective effect of caffeic acid against inflammation injury of primary bovine mammary epithelial cells induced by lipopolysaccharide. J Dairy Sci. 2014 May;97(5):2856-65. PMID: 24612802. Luís Â, Silva F, Sousa S, et al. Antistaphylococcal and biofilm inhibitory activities of gallic, caffeic, and chlorogenic acids. Biofouling. 2014 Jan;30(1):69-79. PMID: 24228999. Tsai CM, Yen GC, Sun FM, et al. Assessment of the anti-invasion potential and mechanism of select cinnamic acid derivatives on human lung adenocarcinoma cells. Mol Pharm. 2013 May 6;10(5):1890-900. PMID: 23560439. Jaganathan SK. Growth inhibition by caffeic acid, one of the phenolic constituents of honey, in HCT 15 colon cancer cells. ScientificWorldJournal. 2012;2012:372345. PMID: 22649289. Pluemsamran T, Onkoksoong T, Panich U. Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells. Photochem Photobiol. 2012 Jul-Aug;88(4):961-8. PMID: 22360712. " Carc., Xi Not dangerous goods. C0145 Calcitriol 50 µg 197.7 Active form of vitamin D, regulates dietary Ca2+ absorption; VDR agonist. (1α,3β,5Z,7E)-9,10-Secocholesta-5,710(19)-triene-1,3,25-triol 1α,25-Dihydroxyvitamin D3 32222-06-3 ≥97% 416.64 C27H44O3 CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C Air, light and moisture sensitive. Dry Ice -80°C Slightly soluble in ethanol, ethyl acetate. Soluble in DMSO "Albert B, Hahn H. Interaction of hedgehog and vitamin D signaling pathways in basal cell carcinomas. Adv Exp Med Biol. 2014;810:329-41. PMID: 25207374. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014;810:282-302. PMID: 25207372. Adamczak DM, Nowak JK, Frydrychowicz M, et al. The role of Toll-like receptors and vitamin D in diabetes mellitus type 1--a review. Scand J Immunol. 2014 Aug;80(2):75-84. PMID: 24845558. Vojinovic J. Vitamin D receptor agonists' anti-inflammatory properties. Ann N Y Acad Sci. 2014 May;1317:47-56. PMID: 24754474. " T+ "UN number: 2811 Class: 6.1 Packing group: I Proper shipping name: Toxic solids, organic, n.o.s. (Calcitriol) Reportable quantity (RQ): Marine pollutant: No Poison inhalation hazard: No" C0145 Calcitriol 5 x 50 µg 593.2 Active form of vitamin D, regulates dietary Ca2+ absorption; VDR agonist. (1α,3β,5Z,7E)-9,10-Secocholesta-5,710(19)-triene-1,3,25-triol 1α,25-Dihydroxyvitamin D3 32222-06-3 ≥97% 416.64 C27H44O3 CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C Air, light and moisture sensitive. Dry Ice -80°C Slightly soluble in ethanol, ethyl acetate. Soluble in DMSO "Albert B, Hahn H. Interaction of hedgehog and vitamin D signaling pathways in basal cell carcinomas. Adv Exp Med Biol. 2014;810:329-41. PMID: 25207374. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014;810:282-302. PMID: 25207372. Adamczak DM, Nowak JK, Frydrychowicz M, et al. The role of Toll-like receptors and vitamin D in diabetes mellitus type 1--a review. Scand J Immunol. 2014 Aug;80(2):75-84. PMID: 24845558. Vojinovic J. Vitamin D receptor agonists' anti-inflammatory properties. Ann N Y Acad Sci. 2014 May;1317:47-56. PMID: 24754474. " T+ "UN number: 2811 Class: 6.1 Packing group: I Proper shipping name: Toxic solids, organic, n.o.s. (Calcitriol) Reportable quantity (RQ): Marine pollutant: No Poison inhalation hazard: No" C0145 Calcitriol 1 mg 632.8 Active form of vitamin D, regulates dietary Ca2+ absorption; VDR agonist. (1α,3β,5Z,7E)-9,10-Secocholesta-5,710(19)-triene-1,3,25-triol 1α,25-Dihydroxyvitamin D3 32222-06-3 ≥97% 416.64 C27H44O3 CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C Air, light and moisture sensitive. Dry Ice -80°C Slightly soluble in ethanol, ethyl acetate. Soluble in DMSO "Albert B, Hahn H. Interaction of hedgehog and vitamin D signaling pathways in basal cell carcinomas. Adv Exp Med Biol. 2014;810:329-41. PMID: 25207374. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014;810:282-302. PMID: 25207372. Adamczak DM, Nowak JK, Frydrychowicz M, et al. The role of Toll-like receptors and vitamin D in diabetes mellitus type 1--a review. Scand J Immunol. 2014 Aug;80(2):75-84. PMID: 24845558. Vojinovic J. Vitamin D receptor agonists' anti-inflammatory properties. Ann N Y Acad Sci. 2014 May;1317:47-56. PMID: 24754474. " T+ "UN number: 2811 Class: 6.1 Packing group: I Proper shipping name: Toxic solids, organic, n.o.s. (Calcitriol) Reportable quantity (RQ): Marine pollutant: No Poison inhalation hazard: No" C0147 Calcium Folinate Pentahydrate 100 mg 64.6 Folate source co-administered with methotrexate; potential thymidylate synthase inhibitor. N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4- oxo-6-pteridinyl)methyl]-amino]benzoyl]-L-glutamic acid calcium salt pentahydrate Leucovorin; 5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt 6035-45-6 ≥95% 601.59 C20H21CaN7O7.5H2O C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2] Ambient 4°C Soluble in water. Insoluble in ethanol "Chen C, Tian L, Zhang M, et al. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. Dig Dis Sci. 2013 Nov;58(11):3134-43. PMID: 23979434. Payet B, Fabre G, Tubiana N, et al. Plasma kinetic study of folinic acid and 5-methyltetrahydrofolate in healthy volunteers and cancer patients by high-performance liquid chromatography. Cancer Chemother Pharmacol. 1987;19(4):319-25. PMID: 3496173. " Xi Not dangerous goods. C0147 Calcium Folinate Pentahydrate 500 mg 272.6 Folate source co-administered with methotrexate; potential thymidylate synthase inhibitor. N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4- oxo-6-pteridinyl)methyl]-amino]benzoyl]-L-glutamic acid calcium salt pentahydrate Leucovorin; 5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt 6035-45-6 ≥95% 601.59 C20H21CaN7O7.5H2O C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2] Ambient 4°C Soluble in water. Insoluble in ethanol "Chen C, Tian L, Zhang M, et al. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. Dig Dis Sci. 2013 Nov;58(11):3134-43. PMID: 23979434. Payet B, Fabre G, Tubiana N, et al. Plasma kinetic study of folinic acid and 5-methyltetrahydrofolate in healthy volunteers and cancer patients by high-performance liquid chromatography. Cancer Chemother Pharmacol. 1987;19(4):319-25. PMID: 3496173. " Xi Not dangerous goods. C0147 Calcium Folinate Pentahydrate 1 g 457.6 Folate source co-administered with methotrexate; potential thymidylate synthase inhibitor. N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4- oxo-6-pteridinyl)methyl]-amino]benzoyl]-L-glutamic acid calcium salt pentahydrate Leucovorin; 5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt 6035-45-6 ≥95% 601.59 C20H21CaN7O7.5H2O C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2] Ambient 4°C Soluble in water. Insoluble in ethanol "Chen C, Tian L, Zhang M, et al. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. Dig Dis Sci. 2013 Nov;58(11):3134-43. PMID: 23979434. Payet B, Fabre G, Tubiana N, et al. Plasma kinetic study of folinic acid and 5-methyltetrahydrofolate in healthy volunteers and cancer patients by high-performance liquid chromatography. Cancer Chemother Pharmacol. 1987;19(4):319-25. PMID: 3496173. " Xi Not dangerous goods. C0150 Camptothecin 25 mg 27.2 Quinolone alkaloid precursor of irinotecan, originally found in Camptotheca; topoisomerase I inhibitor. (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino- [1,2-b]quinoline-3,14(4H,12H)-dione 7689-03-4 ≥98% 348.35 C20H16N2O4 CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O Ambient -20°C Soluble in DMSO. "Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118. Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844. Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644. " T "UN number: 1544 Class: 6.1 Packing group: III Proper shipping name: Alkaloids, solid, n.o.s. ((S)-(+)-Camptothecin) Marine pollutant: No. Poison Inhalation Hazard: No" C0150 Camptothecin 100 mg 54.4 Quinolone alkaloid precursor of irinotecan, originally found in Camptotheca; topoisomerase I inhibitor. (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino- [1,2-b]quinoline-3,14(4H,12H)-dione 7689-03-4 ≥98% 348.35 C20H16N2O4 CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O Ambient -20°C Soluble in DMSO. "Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118. Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844. Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644. " T "UN number: 1544 Class: 6.1 Packing group: III Proper shipping name: Alkaloids, solid, n.o.s. ((S)-(+)-Camptothecin) Marine pollutant: No. Poison Inhalation Hazard: No" C0150 Camptothecin 250 mg 133.5 Quinolone alkaloid precursor of irinotecan, originally found in Camptotheca; topoisomerase I inhibitor. (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino- [1,2-b]quinoline-3,14(4H,12H)-dione 7689-03-4 ≥98% 348.35 C20H16N2O4 CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O Ambient -20°C Soluble in DMSO. "Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118. Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844. Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644. " T "UN number: 1544 Class: 6.1 Packing group: III Proper shipping name: Alkaloids, solid, n.o.s. ((S)-(+)-Camptothecin) Marine pollutant: No. Poison Inhalation Hazard: No" C0155 10-Hydroxycamptothecin 25 mg 78.2 Camptothecin derivative; topoisomerase I inhibitor. (S)-4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizi,2-b]quinoline-3,14(4H,12H)-dione 19685-09-7 ≥96% 364.35 C20H16N2O5 CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O Ambient -20°C Soluble in DMSO. "Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118. Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844. Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644. " Xi Not dangerous goods. C0155 10-Hydroxycamptothecin 100 mg 218.5 Camptothecin derivative; topoisomerase I inhibitor. (S)-4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizi,2-b]quinoline-3,14(4H,12H)-dione 19685-09-7 ≥96% 364.35 C20H16N2O5 CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O Ambient -20°C Soluble in DMSO. "Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118. Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844. Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644. " Xi Not dangerous goods. C0168 Canthaxanthin 5 g 79.1 Carotenoid terpene pigment found in various plant sources. β,β-Carotene-4,4'-dione 514-78-3 ≥9% 564.84 C40H52O2 CC1=C(C(CCC1=O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)CCC2(C)C)C)C)C Ambient Ambient Soluble in chloroform or oil. Slightly soluble in methanol. "Chew BP, Park JS. Carotenoid action on the immune response. J Nutr. 2004 Jan;134(1):257S-261S. PMID: 14704330. Stahl W, Sies H. The role of carotenoids and retinoids in gap junctional communication. Int J Vitam Nutr Res. 1998;68(6):354-9. PMID: 9857261. Palozza P, Luberto C, Ricci P, et al. Effect of beta-carotene and canthaxanthin on tert-butyl hydroperoxide-induced lipid peroxidation in murine normal and tumor thymocytes. Arch Biochem Biophys. 1996 Jan 15;325(2):145-51. PMID: 8561491. Pung A, Rundhaug JE, Yoshizawa CN, et al. Beta-carotene and canthaxanthin inhibit chemically- and physically-induced neoplastic transformation in 10T1/2 cells. Carcinogenesis. 1988 Sep;9(9):1533-9. PMID: 3136943. " Not dangerous goods. C0168 Canthaxanthin 10 g 99.6 Carotenoid terpene pigment found in various plant sources. β,β-Carotene-4,4'-dione 514-78-3 ≥9% 564.84 C40H52O2 CC1=C(C(CCC1=O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)CCC2(C)C)C)C)C Ambient Ambient Soluble in chloroform or oil. Slightly soluble in methanol. "Chew BP, Park JS. Carotenoid action on the immune response. J Nutr. 2004 Jan;134(1):257S-261S. PMID: 14704330. Stahl W, Sies H. The role of carotenoids and retinoids in gap junctional communication. Int J Vitam Nutr Res. 1998;68(6):354-9. PMID: 9857261. Palozza P, Luberto C, Ricci P, et al. Effect of beta-carotene and canthaxanthin on tert-butyl hydroperoxide-induced lipid peroxidation in murine normal and tumor thymocytes. Arch Biochem Biophys. 1996 Jan 15;325(2):145-51. PMID: 8561491. Pung A, Rundhaug JE, Yoshizawa CN, et al. Beta-carotene and canthaxanthin inhibit chemically- and physically-induced neoplastic transformation in 10T1/2 cells. Carcinogenesis. 1988 Sep;9(9):1533-9. PMID: 3136943. " Not dangerous goods. C0168 Canthaxanthin 25 g 163.8 Carotenoid terpene pigment found in various plant sources. β,β-Carotene-4,4'-dione 514-78-3 ≥9% 564.84 C40H52O2 CC1=C(C(CCC1=O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)CCC2(C)C)C)C)C Ambient Ambient Soluble in chloroform or oil. Slightly soluble in methanol. "Chew BP, Park JS. Carotenoid action on the immune response. J Nutr. 2004 Jan;134(1):257S-261S. PMID: 14704330. Stahl W, Sies H. The role of carotenoids and retinoids in gap junctional communication. Int J Vitam Nutr Res. 1998;68(6):354-9. PMID: 9857261. Palozza P, Luberto C, Ricci P, et al. Effect of beta-carotene and canthaxanthin on tert-butyl hydroperoxide-induced lipid peroxidation in murine normal and tumor thymocytes. Arch Biochem Biophys. 1996 Jan 15;325(2):145-51. PMID: 8561491. Pung A, Rundhaug JE, Yoshizawa CN, et al. Beta-carotene and canthaxanthin inhibit chemically- and physically-induced neoplastic transformation in 10T1/2 cells. Carcinogenesis. 1988 Sep;9(9):1533-9. PMID: 3136943. " Not dangerous goods. C0169 Carbenoxolone Disodium 1 g 50.2 Synthetic derivative of glycyrrhizin; connexin and 11β-hydroxysteroid dehydrogenase inhibitor. (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean- 12-en-29-oic acid 18β-Glycyrrhetic acid hydrogen succinate; Carbenoxalone 7421-40-1 ≥97% 614.7 C34H48Na2O7 CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+] Ambient Ambient Soluble in water. Insoluble in chloroform. "Chen G, Park CK, Xie RG, et al. Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain. 2014 Aug;137(Pt 8):2193-209. PMID: 24919967. Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920. Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899. Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952. Chávez-Piña AE, Tapia-Álvarez GR, Reyes-Ramínrez A, et al. Carbenoxolone gastroprotective mechanism: participation of nitric oxide/(c) GMP/K(ATP) pathway in ethanol-induced gastric injury in the rat. Fundam Clin Pharmacol. 2011 Dec;25(6):717-22. PMID: 21105909. " Xn, Xi Not dangerous goods. C0169 Carbenoxolone Disodium 5 g 160.2 Synthetic derivative of glycyrrhizin; connexin and 11β-hydroxysteroid dehydrogenase inhibitor. (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean- 12-en-29-oic acid 18β-Glycyrrhetic acid hydrogen succinate; Carbenoxalone 7421-40-1 ≥97% 614.7 C34H48Na2O7 CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+] Ambient Ambient Soluble in water. Insoluble in chloroform. "Chen G, Park CK, Xie RG, et al. Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain. 2014 Aug;137(Pt 8):2193-209. PMID: 24919967. Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920. Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899. Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952. Chávez-Piña AE, Tapia-Álvarez GR, Reyes-Ramínrez A, et al. Carbenoxolone gastroprotective mechanism: participation of nitric oxide/(c) GMP/K(ATP) pathway in ethanol-induced gastric injury in the rat. Fundam Clin Pharmacol. 2011 Dec;25(6):717-22. PMID: 21105909. " Xn, Xi Not dangerous goods. C0169 Carbenoxolone Disodium 25 g 510.3 Synthetic derivative of glycyrrhizin; connexin and 11β-hydroxysteroid dehydrogenase inhibitor. (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean- 12-en-29-oic acid 18β-Glycyrrhetic acid hydrogen succinate; Carbenoxalone 7421-40-1 ≥97% 614.7 C34H48Na2O7 CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+] Ambient Ambient Soluble in water. Insoluble in chloroform. "Chen G, Park CK, Xie RG, et al. Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain. 2014 Aug;137(Pt 8):2193-209. PMID: 24919967. Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920. Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899. Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952. Chávez-Piña AE, Tapia-Álvarez GR, Reyes-Ramínrez A, et al. Carbenoxolone gastroprotective mechanism: participation of nitric oxide/(c) GMP/K(ATP) pathway in ethanol-induced gastric injury in the rat. Fundam Clin Pharmacol. 2011 Dec;25(6):717-22. PMID: 21105909. " Xn, Xi Not dangerous goods. C0171 Carboplatin 25 mg 40.7 Pt-based DNA cross-linker. (SP-4-2)-Diammine-[1,1-cyclobutanedi(carboxylato- κO)(2-)]platinum Paraplati; cis-Diammine[1,1 cyclobutane dicarboxylato] platinum 41575-94-4 ≥98% 371.25 C6H12N2O4Pt C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2] Ambient -20°C Soluble in water. "Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823. Chen X, Wu Y, Dong H, et al. Platinum-based agents for individualized cancer treatment. Curr Mol Med. 2013 Dec;13(10):1603-12. PMID: 24206132. Ang WH, Myint M, Lippard SJ. Transcription inhibition by platinum-DNA cross-links in live mammalian cells. J Am Chem Soc. 2010 Jun 2;132(21):7429-35. PMID: 20443565. " Xn, Carc., Repr. Not dangerous goods. C0171 Carboplatin 100 mg 149.5 Pt-based DNA cross-linker. (SP-4-2)-Diammine-[1,1-cyclobutanedi(carboxylato- κO)(2-)]platinum Paraplati; cis-Diammine[1,1 cyclobutane dicarboxylato] platinum 41575-94-4 ≥98% 371.25 C6H12N2O4Pt C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2] Ambient -20°C Soluble in water. "Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823. Chen X, Wu Y, Dong H, et al. Platinum-based agents for individualized cancer treatment. Curr Mol Med. 2013 Dec;13(10):1603-12. PMID: 24206132. Ang WH, Myint M, Lippard SJ. Transcription inhibition by platinum-DNA cross-links in live mammalian cells. J Am Chem Soc. 2010 Jun 2;132(21):7429-35. PMID: 20443565. " Xn, Carc., Repr. Not dangerous goods. C0171 Carboplatin 250 mg 305.9 Pt-based DNA cross-linker. (SP-4-2)-Diammine-[1,1-cyclobutanedi(carboxylato- κO)(2-)]platinum Paraplati; cis-Diammine[1,1 cyclobutane dicarboxylato] platinum 41575-94-4 ≥98% 371.25 C6H12N2O4Pt C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2] Ambient -20°C Soluble in water. "Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823. Chen X, Wu Y, Dong H, et al. Platinum-based agents for individualized cancer treatment. Curr Mol Med. 2013 Dec;13(10):1603-12. PMID: 24206132. Ang WH, Myint M, Lippard SJ. Transcription inhibition by platinum-DNA cross-links in live mammalian cells. J Am Chem Soc. 2010 Jun 2;132(21):7429-35. PMID: 20443565. " Xn, Carc., Repr. Not dangerous goods. C0269 β-Carotene 1 g 20.4 Red-orange terpene pigment found in various plants and fruits, vitamin A prodrug. β,β-Carotene Carotaben; Provatene; Solatene 7235-40-7 ≥97% 536.87 C40H56 CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CCCC2(C)C)C)C)C Ambient -20°C Insoluble in water. Sparingly soluble in ethanol. Soluble in benzene or chloroform. "Abdel-Mageed WM, Bayoumi SA, Salama AA, et al. Antioxidant lipoxygenase inhibitors from the leaf extracts of Simmondsia chinensis. Asian Pac J Trop Med. 2014 Sep;7S1:S521-6. PMID: 25312177. Berti AP, Düsman E, Mariucci RG, et al. Antimutagenic and radioprotective activities of beta-carotene against the biological effects of iodine-131 radiopharmaceutical in Wistar rats. Genet Mol Res. 2014 Mar 31;13(1):2248-58. PMID: 24737473. Gloria NF, Soares N, Brand C, et al. Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines. Anticancer Res. 2014 Mar;34(3):1377-86. PMID: 24596385. Silva LS, de Miranda AM, de Brito Magalhães CL, et al. Diet supplementation with beta-carotene improves the serum lipid profile in rats fed a cholesterol-enriched diet. J Physiol Biochem. 2013 Dec;69(4):811-20. PMID: 23645541. Di Tomo P, Canali R, Ciavardelli D, et al. β-Carotene and lycopene affect endothelial response to TNF-α reducing nitro-oxidative stress and interaction with monocytes. Mol Nutr Food Res. 2012 Feb;56(2):217-27. PMID: 22162208. Amengual J, Gouranton E, van Helden YG, et al. Beta-carotene reduces body adiposity of mice via BCMO1. PLoS One. 2011;6(6):e20644. PMID: 21673813. " Xn, Xi Not dangerous goods. C0269 β-Carotene 5 g 40.7 Red-orange terpene pigment found in various plants and fruits, vitamin A prodrug. β,β-Carotene Carotaben; Provatene; Solatene 7235-40-7 ≥97% 536.87 C40H56 CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CCCC2(C)C)C)C)C Ambient -20°C Insoluble in water. Sparingly soluble in ethanol. Soluble in benzene or chloroform. "Abdel-Mageed WM, Bayoumi SA, Salama AA, et al. Antioxidant lipoxygenase inhibitors from the leaf extracts of Simmondsia chinensis. Asian Pac J Trop Med. 2014 Sep;7S1:S521-6. PMID: 25312177. Berti AP, Düsman E, Mariucci RG, et al. Antimutagenic and radioprotective activities of beta-carotene against the biological effects of iodine-131 radiopharmaceutical in Wistar rats. Genet Mol Res. 2014 Mar 31;13(1):2248-58. PMID: 24737473. Gloria NF, Soares N, Brand C, et al. Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines. Anticancer Res. 2014 Mar;34(3):1377-86. PMID: 24596385. Silva LS, de Miranda AM, de Brito Magalhães CL, et al. Diet supplementation with beta-carotene improves the serum lipid profile in rats fed a cholesterol-enriched diet. J Physiol Biochem. 2013 Dec;69(4):811-20. PMID: 23645541. Di Tomo P, Canali R, Ciavardelli D, et al. β-Carotene and lycopene affect endothelial response to TNF-α reducing nitro-oxidative stress and interaction with monocytes. Mol Nutr Food Res. 2012 Feb;56(2):217-27. PMID: 22162208. Amengual J, Gouranton E, van Helden YG, et al. Beta-carotene reduces body adiposity of mice via BCMO1. PLoS One. 2011;6(6):e20644. PMID: 21673813. " Xn, Xi Not dangerous goods. C0368 Carveol 5 g 52.3 Terpene alcohol found in spearmint oil; TRPV3 agonist. p-Mentha-6,8-dien-2-ol 99-48-9 ≥98% 152.23 C10H16O CC1=CCC(CC1O)C(=C)C Ambient Ambient Insoluble in water. Soluble in ethanol, or DMSO. "Yang JY, Kim MG, Lee SE, et al. Acaricidal activities against house dust mites of spearmint oil and its constituents. Planta Med. 2014 Feb;80(2-3):165-70. PMID: 24488719. Bhatia SP, McGinty D, Letizia CS, et al. Fragrance material review on carveol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S85-7. PMID: 18640224. Vogt-Eisele AK, Weber K, Sherkheli MA, et al. Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40. PMID: 17420775. Chen J, Lu M, Jing Y, et al. The synthesis of L-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells. Bioorg Med Chem. 2006 Oct 1;14(19):6539-47. PMID: 16806947. " Xi Not dangerous goods. C0368 Carveol 25 g 170.7 Terpene alcohol found in spearmint oil; TRPV3 agonist. p-Mentha-6,8-dien-2-ol 99-48-9 ≥98% 152.23 C10H16O CC1=CCC(CC1O)C(=C)C Ambient Ambient Insoluble in water. Soluble in ethanol, or DMSO. "Yang JY, Kim MG, Lee SE, et al. Acaricidal activities against house dust mites of spearmint oil and its constituents. Planta Med. 2014 Feb;80(2-3):165-70. PMID: 24488719. Bhatia SP, McGinty D, Letizia CS, et al. Fragrance material review on carveol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S85-7. PMID: 18640224. Vogt-Eisele AK, Weber K, Sherkheli MA, et al. Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40. PMID: 17420775. Chen J, Lu M, Jing Y, et al. The synthesis of L-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells. Bioorg Med Chem. 2006 Oct 1;14(19):6539-47. PMID: 16806947. " Xi Not dangerous goods. C2800 Chalcone 25 g 44.9 Enone. 1,3-Diphenyl-2-propen-1-one Chalkone; trans-Benzylideneacetophenone 94-41-7 ≥97% 208.26 C15H12O C1=CC=C(C=C1)C=CC(=O)C2=CC=CC=C2 Ambient Ambient Insoluble in water. Slightly soluble in ethanol. "Wu JZ, Cheng CC, Shen LL, et al. Synthetic Chalcones with Potent Antioxidant Ability on H2O2-Induced Apoptosis in PC12 Cells. Int J Mol Sci. 2014 Oct 14;15(10):18525-18539. PMID: 25318055. Jantan I, Bukhari SN, Adekoya OA, et al. Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines. Drug Des Devel Ther. 2014 Sep 16;8:1405-18. PMID: 25258510. Abdellatif KR, Elshemy HA, Salama SA, et al. Synthesis, characterization and biological evaluation of novel 4'-fluoro-2'-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. J Enzyme Inhib Med Chem. 2014 Sep 8:1-8. PMID: 25198887. Karthikeyan C, Narayana Moorthy NS, Ramasamy S, et al. Advances in Chalcones with Anticancer Activities. Recent Pat Anticancer Drug Discov. 2014 Aug 19. [Epub ahead of print]. PMID: 25138130. Shivahare R, Korthikunta V, Chandasana H, et al. Synthesis, structure-activity relationships, and biological studies of chromenochalcones as potential antileishmanial agents. J Med Chem. 2014 Apr 24;57(8):3342-57. PMID: 24635539. " Xn, Xi Not dangerous goods. C2800 Chalcone 100 g 104.6 Enone. 1,3-Diphenyl-2-propen-1-one Chalkone; trans-Benzylideneacetophenone 94-41-7 ≥97% 208.26 C15H12O C1=CC=C(C=C1)C=CC(=O)C2=CC=CC=C2 Ambient Ambient Insoluble in water. Slightly soluble in ethanol. "Wu JZ, Cheng CC, Shen LL, et al. Synthetic Chalcones with Potent Antioxidant Ability on H2O2-Induced Apoptosis in PC12 Cells. Int J Mol Sci. 2014 Oct 14;15(10):18525-18539. PMID: 25318055. Jantan I, Bukhari SN, Adekoya OA, et al. Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines. Drug Des Devel Ther. 2014 Sep 16;8:1405-18. PMID: 25258510. Abdellatif KR, Elshemy HA, Salama SA, et al. Synthesis, characterization and biological evaluation of novel 4'-fluoro-2'-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. J Enzyme Inhib Med Chem. 2014 Sep 8:1-8. PMID: 25198887. Karthikeyan C, Narayana Moorthy NS, Ramasamy S, et al. Advances in Chalcones with Anticancer Activities. Recent Pat Anticancer Drug Discov. 2014 Aug 19. [Epub ahead of print]. PMID: 25138130. Shivahare R, Korthikunta V, Chandasana H, et al. Synthesis, structure-activity relationships, and biological studies of chromenochalcones as potential antileishmanial agents. J Med Chem. 2014 Apr 24;57(8):3342-57. PMID: 24635539. " Xn, Xi Not dangerous goods. C2816 Cheirolin 25 mg 152.4 Naturally produced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-3-(methylsulfonyl)-propane 505-34-0 ≥97% 179.26 C5H9NO2S2 CS(=O)(=O)CCCN=C=S Ambient -20°C Slightly soluble in water, ether; freely soluble in alcohol, chloroform, ethyl acetate. Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058. Not dangerous goods. C2816 Cheirolin 50 mg 255 Naturally produced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-3-(methylsulfonyl)-propane 505-34-0 ≥97% 179.26 C5H9NO2S2 CS(=O)(=O)CCCN=C=S Ambient -20°C Slightly soluble in water, ether; freely soluble in alcohol, chloroform, ethyl acetate. Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058. Not dangerous goods. C2816 Cheirolin 100 mg 468.2 Naturally produced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-3-(methylsulfonyl)-propane 505-34-0 ≥97% 179.26 C5H9NO2S2 CS(=O)(=O)CCCN=C=S Ambient -20°C Slightly soluble in water, ether; freely soluble in alcohol, chloroform, ethyl acetate. Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058. Not dangerous goods. C2816 Cheirolin 500 mg 1517.1 Naturally produced ITC, sulfonyl analog of sulforaphane. 1-Isothiocyanato-3-(methylsulfonyl)-propane 505-34-0 ≥97% 179.26 C5H9NO2S2 CS(=O)(=O)CCCN=C=S Ambient -20°C Slightly soluble in water, ether; freely soluble in alcohol, chloroform, ethyl acetate. Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058. Not dangerous goods. C2944 Chlorogenic Acid (from Lonicera) 100 mg 25.2 Polyphenol derivative of caffeic acid found in Lonicera; DNMT and G6P translocase inhibitor, potential pepsin inhibitor. [1S-(1α,3β,4α,5α)]-3-[[3-(3,4-Dihydroxyphenyl)-1- oxo-2-propenyl]oxy]-1,4,5-trihydroxycyclohexane- carboxylic acid 3-Caffeoylquinic acid 327-97-9 ≥98% 354.31 C16H18O9 C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O Ambient Ambient Soluble in ethanol or acetone. "Zeng HJ, Liang HL, You J, et al. Study on the binding of chlorogenic acid to pepsin by spectral and molecular docking. Luminescence. 2013 Dec 12. [Epub ahead of print]. PMID: 24339327. Luís A, Silva F, Sousa S, et al. Antistaphylococcal and biofilm inhibitory activities of gallic, caffeic, and chlorogenic acids. Biofouling. 2014 Jan;30(1):69-79. PMID: 24228999. Shi H, Dong L, Jiang J, et al. Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology. 2013 Jan 7;303:107-14. PMID: 23146752. Teraoka M, Nakaso K, Kusumoto C, et al. Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells. J Clin Biochem Nutr. 2012 Sep;51(2):122-7. PMID: 22962530. Lou Z, Wang H, Zhu S, et al. Antibacterial activity and mechanism of action of chlorogenic acid. J Food Sci. 2011 Aug;76(6):M398-403. PMID: 22417510. Qin HD, Shi YQ, Liu ZH, et al. Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction. Int Immunopharmacol. 2010 Sep;10(9):1135-41. PMID: 20620227. Belkaid A, Currie JC, Desgagnés J, et al. The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression. Cancer Cell Int. 2006 Mar 27;6:7. PMID: 16566826. Lee WJ, Zhu BT. Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. " Xn Not dangerous goods.